Selective Serotonin Reuptake Inhibitors (SSRIs) – Antidepressants (Nursing)

by Prof. Lawes

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    00:00 Hi, welcome to our video series on antidepressants.

    00:04 Now in this one, we're gonna specifically look at selective serotonin reuptake inhibitors.

    00:11 Ready? Alright, here we go.

    00:14 Now, SSRIs increase the circulating serotonin in the synapses by blocking the reuptake of serotonin in the neuron.

    00:23 Really? So what? Alright, let's break that down.

    00:27 Okay, do we want more circulating serotonin? Yes. Here's why.

    00:33 Serotonin is a neurotransmitter, right? That's a messenger.

    00:38 So serotonin is a neurotransmitter believed to help regulate -- ready for this list? Your mood, social behavior, appetite, digestion, sleep, memory, sexual desire, and function. Okay? That's a really long list. So make sure you kinda take some notes on that.

    01:01 We're talking about mood, number one, and social behavior.

    01:04 Those are really the things we're after. But it also can impact appetite and digestion.

    01:10 Hey, these guys are known to kind of cause weight gain.

    01:13 Now, it can mess with your sleep, sometimes it can keep you up.

    01:17 It messes with your memory sometimes.

    01:20 It impacts your memory, sexual desire and function.

    01:24 So these are great in helping certain patients feel better but they can have a series of side effects that may make someone hesitant to continue taking the medication.

    01:34 So first of all, let's lay the groundwork.

    01:37 SSRIs increase circulating serotonin in the synapses because they block it from being reuptaken into the neuron so instead of having a serotonin up in the neuron, it's still out on those synapses, that's a good thing. We want more of that available.

    01:55 See, the theory is that serotonin, if there's not enough of it available in those synapses, is linked to a sad or depressed mood.

    02:05 Let me give you some examples.

    02:07 Now in this one, we did make an exception, we normally don't put the trademark name in there but I was pretty sure you've seen some of these names before or heard of them so that's why we included them.

    02:18 But on the NCLEX exam, the only words that will be there are the generic.

    02:22 So the first one, paroxetine, that's Paxil.

    02:25 You won't see Paxil because that's a trade name in the parenthesis on the NCLEX.

    02:30 You'll see the generic name, paroxetine.

    02:33 So let's -- let me give you 5 or so more examples.

    02:36 Citalopram, otherwise known as Celexa, that's the trade name.

    02:40 Fluoxetine, an old friend Prozac. That one has been around forever.

    02:45 It's a really cheap script but it's very effective for certain patients.

    02:50 Now the other three, we've got Zoloft, Luvox, and Lexapro.

    02:55 Okay, now those are the names that you won't see on the test so make sure you look at the generic names.

    03:01 I'd recommend pausing, spending a couple minutes here, just kinda practicing making sure that you know these names.

    03:12 Okay, now that you've practiced the names, let's go on.

    03:16 So what can we use SSRIs for? Well, since it's an antidepressant, the first one seems kinda obvious, doesn't it? They would use it for depression.

    03:28 But they're also pretty good for OCD, some of the things of obsessive-compulsive disorder.

    03:34 Also social anxiety, post-traumatic stress syndrome, and panic disorder.

    03:40 Now, these are different than depression but they often go hand in hand with depression.

    03:45 So this particular group of antidepressants, SSRIs, can be really good in treating these other disorders.

    03:53 Now here's your job. Figure out a way you wanna kinda group those together.

    03:57 Chunk that information to say what other uses can we use SSRIs for besides depression.

    04:04 Now, it can also be helpful in eating disorders, premenstrual dysphoric disorder.

    04:11 Now, that is -- premenstrual dysphoric disorder comes in synchrony with your menstrual period.

    04:17 So obviously, this is a disorder that we treat in women and it comes right around with perfect timing with your menstrual period so we know that this is what this is.

    04:27 You have pretty intense feelings of sadness and depression but it's a couple weeks a month.

    04:33 So you can work with your health care provider, with your OB-GYN, and come up with a treatment with SSRIs is usually pretty effective rather quickly.

    04:41 Now also we've got enuresis.

    04:43 That's kind of an odd one for you to remember but that's also helpful.

    04:47 Remember when something seems so different than the other things, it's easier to remember.

    04:53 So take a little time here, hang out, see if you can refresh and review this information to make sure you have it solid before we go on to the next section.

    About the Lecture

    The lecture Selective Serotonin Reuptake Inhibitors (SSRIs) – Antidepressants (Nursing) by Prof. Lawes is from the course Central Nervous System (CNS) Medications (Nursing).

    Included Quiz Questions

    1. Citalopram
    2. Clozapine
    3. Thiopentone
    4. Diazepam
    1. Depression
    2. Social anxiety disorder
    3. Eating disorder
    4. Panic disorder
    5. Oliguria

    Author of lecture Selective Serotonin Reuptake Inhibitors (SSRIs) – Antidepressants (Nursing)

     Prof. Lawes

    Prof. Lawes

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