Let's move on to a question regarding benzodiazepines. The
following statement about benzodiazepines is true.
A. Benzodiazepines act through the excitation of GABA on the
GABA A receptor-chloride ion channel macromolecular complex.
B. Benzos bind to a region between the alpha and beta portions
of the GABA A complex. C. Benzodiazepines bind to a region
on the alpha portion or benzos bind to a region between the
alpha and gamma portions. So which one is true?
Good. So you chose D which says that benzodiazepines bind to
a region between the alpha and gamma portions of the A complex.
Let's move on to comparing Ben and Barb, and this is how we commonly
call them in clinical practice. Pick the correct statement.
A. Both barbiturates and benzodiazepines can be reversed by
flumazenil. B. Both barbiturates and benzodiazepines act by
binding to a specific site on the subunit of the GABA A complex.
C. Both barbiturates and benzos inhibit the actions of GABA
on a GABA A receptor complex. And D, both benzos and
barbiturates have strong antiseizure activity at low doses.
If you picked C, you are right. So let's take a look at these
answers. Both barbiturates and benzodiazepines can be reversed
by flumazenil. Well remember that barbiturates binding site is
inside the membrane itself and far away from the flumazenil
binding site. So no. Barbiturates are not reversed by flumazenil
while benzodiazepines are. B, both barbiturates and benzos
act by binding to a specific alpha unit. That's not quite
true. They actually bind between the alpha and gamma subunits.
And D is wrong, because it says here both barbiturates and
benzodiazepines have strong antiseizure activity at low
doses, no. Barbiturates have antiseizure activity at medium
doses and benzos have antiseizure activity at high doses.