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Questions – Sedative Hypnotics
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Slides Question Sedative Hypnotics.pdf
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Reference List Pharmacology.pdf
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00:01 Ok, so let's move on to some questions on these drugs. 00:05 Question 1: The following statement about benzodiazepines is true. 00:12 A. Benzodiazepines act through the excitation of GABA on the GABA A receptor-chloride ion channel macromolecular complex. 00:23 B. Benzodiazepines bind to a region between the alpha and beta portions of the GABAA receptor-chloride ion channel macromolecular complex. 00:35 C. Benzodiazepines bind to a region on the alpha portion of the GABAA receptor ion complex. 00:42 And finally D: Benzodiazepines bind to a region between the α and γ portions of the GABAA receptor-chloride ion channel macromolecular complex. 00:57 Right, D is the correct answer. It's important to know where these drugs are binding on the GABA-receptor because it's a favourite question on our exams. 01:07 Let's do another question. Pick the correct statement. 01:11 A: Both barbiturates and benzodiazepines can be reversed by flumazenil. 01:18 B: Both barbiturates and benzodiazepines act by binding to a specific α subunit of the GABAA receptor complex. 01:27 C: Both barbiturates and benzos enhance the inhibitory actions of GABA on the GABAA receptor complex. 01:37 And finally D: Both benzodiazepines and barbiturates have strong anti-seizure activity at low doses. 01:47 If you picked C, you are right. So let's take a look at these answers. 01:51 Answer choice A states that both barbiturates and benzodiazepines can be reversed by flumazenil. 01:58 Remember that the barbiturate binding site is inside the membrane itself and far away from the flumazenil binding site. 02:06 So no, barbiturates are not reversed by flumazenil while benzodiazepines are. 02:11 Answer choice B states that both barbiturates and benzos act by binding to a specific alpha unit. That's not quite true. They actually bind between the alpha and gamma subunits. 02:24 And D is wrong because both of these drugs don't have strong anti-seizure activity at low doses so it's important to recognize where benzos hand the baton over to barbiturates –it's at the higher end of the diazepine dosage range and the lower end of the barbiturate range
About the Lecture
The lecture Questions – Sedative Hypnotics by Pravin Shukle, MD is from the course CNS - Pharmacology.
Included Quiz Questions
Which statement is correct?
- Benzodiazepines bind to the GABA-a receptor at the interface between the α and γ subunits.
- Benzodiazepines are more potent than barbiturates.
- Benzodiazepines work by antagonizing the effects of gamma-aminobutyric acid (GABA) in the liver.
- Flumazenil is an antidote to barbiturates.
- Benzodiazepines bind to the GABA-a receptor at the interface solely at the γ subunit.
Author of lecture Questions – Sedative Hypnotics
Pravin Shukle, MD
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Concise questions w/ concise answers. Good for a quick review after study.
Dr Shukle explains all subjects with a lot of knowledge, and very easy to understand. Thank you, Lili B.
The edition of the video is very confused, I Didn´t know if the correct answer was A or C.
