00:01
The subject of this talk is a specific form
of interstitial lung disease called sarcoidosis.
00:05
Now, this disease, you get infiltration of the
lung and extrapulmonary tissue with non-caseating
granulomas. This seems to be a cell mediated
reaction, but the reason for that, why it
happens remains unknown and is probably different
depending on the patient. The thing about
sarcoidosis, a light tuberculosis and lung
cancer, it's one of the three lung diseases
that can have multisystem presentation, because
not only does it affect the lung, but it affects
many extrapulmonary sites. As seen in this
diagram, some of the common
examples are the eyes and the skin, your neurological
system, lymph nodes, cardiac, joint, liver,
and spleen, etc. This means that sarcoid,
when it's chronic, can be very variable in its presentation
depending on the pattern of disease of which
organs have been affected by the disease.
00:58
Importantly, the diagnosis can be made and
needs to be confirmed by a biopsy to show
these non-caseating granulomas which are very
distinctive for the sarcoidosis.
01:09
Clinical presentation of sarcoid, well the
average age of presentation is a young adult,
between 20 and 40. It is probably slightly
more common in women than it is in men.
01:21
It is actually very common in the Afro-Caribbean
populations for reasons which are not clear.
01:25
But still, it is very significantly present
in the Caucasians as well. There are acute
presentations and there are chronic presentations
of sarcoidosis. Acute presentations tend to
be relatively similar. The patient will be
a young adult. They will
present with bilateral hilar lymphadenopathy
which are enlarged lymph nodes visible in
a chest X-ray in the middle of the chest.
And they may have erythema nodosum which is
a skin rash which affects the lower parts
of the leg on the anterior shin when they
will get raised tender lumps which are one or
two centimeters across, and very clinically
obvious and very easy to diagnose as erythema
nodosum.
02:03
The patient will feel a bit unwell, they may
have a bit of a temperature, a bit of sweat,
a bit of arthralgia, pains in their joints,
and may be feeling just a bit miserable under
the weather. This disease, this acute syndrome
is often called Lofgrens syndrome and only
lasts for a few weeks or months and most patients
will resolve spontaneously with no recurrence
to the sarcoid thereafter. And treatment is
often not required.
02:28
Chronic presentation is different. The patient
will present an insidious disease. It comes
on slowly. It can be progressive over time.
It can be stable over time. It can have inflares,
it can have periods where it gets best and gets worse,
waxes and wanes. And the presentation really
depends in which organs are affected, and
that is why chronic sarcoidosis can be very
varied in this presentation because it depends
on which particular organs are involved in
that specific patient. So, if we’are talking
about pulmonary sarcoidosis,
lung involvement, the common presentations
with acute sarcoidosis is bilateral hilar
lymphadenopathy, enlarged lymph nodes, visible
on a chest X-ray and a CT scan. These lymph
nodes tend to be symmetrical and smooth, even
in distribution on both sides. And they don’t
really tend to cause too much in the way since
they can cause a cough. The differential diagnosis
for enlarged lymph nodes in the chest is tuberculosis,
lymphoma and cancer. So serious diseases,
but all of those diseases tend to cause non-symmetrical
enlargement of the lymph nodes. And in many
patients with acute sarcoid, the combination
of symmetrical lymph nodes and erythema nodosum
is adequate in itself to be happy that they
have acute sarcoidosis rather than any of
these other more complicated diseases. As well as
the lymph nodes, patients with
chronic disease may also develop infiltrates
in the lung, and these are normally a reticulonodular
infiltrations in both upper lobes. This leads
to volume loss, and often, you can actually
hear when you listen to the lungs any crepitations
over these. And the patient can be surprisingly
asymptomatic with quite a dramatic chest X-ray.
But eventually, this sort of disease will
cause dyspnoea due to lung loss and restrictive
lung function problems. Occasionally, you
get end-stage sarcoidosis which looks very
much like the UIP form of pulmonary fibrosis
as we discussed in the earlier lecture. And
some of these infiltrates coalesce to form
nodules in the lung which are much more larger
than just the micronodular infiltrate you
might normally get. Very occasionally, you
get patients with ground
glass infiltrates, and thats one of the
presentations that are more severe acute disease
than normal. So this is an example of a chest
X-ray
and you can see in both upper lobes, there
is a sort of interstitial infiltration and
there is distortion of the hilar and loss
of volume. And in some patients
there is a bit of
coalesce lung infiltration where you get more
lump-like material present. And that is just
the areas where there is actually quite extensive
sarcoidosis. You can stage pulmonary
sarcoidosis, and this
is the scheme that’s used for stages not
to four, not having no pulmonary disease,
just extrapulmonary disease only, one being
the classic acute bilateral hilar lymphadenopathy,
BHL presentation, which is unlikely to progress
with 90% of patients for admission. Or you
can have the bilateral hilar lymphadenopathy
presenting with some parenchymal infiltrations,
and these patients are probably a little bit
more likely to progress than just the ones
with the lymph nodes alone. And then there's
the more chronic forms. We have parenchymal
infiltrations which can go into remission but
normally do not, and in fact, can be progressive
over time and eventually to advanced pulmonary
fibrosis stage four disease with marked dyspnea
and restrictive failure.