Congenital Rubella (German Measles) and Cytomegalovirus Infection (CMV)

by Brian Alverson, MD

My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides TORCH Pediatrics.pdf
    • PDF
      Download Lecture Overview
    Report mistake

    00:01 Let’s switch gears one more time to rubella.

    00:05 Rubella is rare in the U.S. because we have a vaccine, the measles-mumps-rubella vaccine, which is a great vaccine.

    00:13 Rubella is an RNA virus.

    00:15 And primary infection is not such a big deal.

    00:20 Patients will get a low-grade fever, they’ll get headache, maybe conjunctivitis, maybe cough and congestion And they will get a classic rash.

    00:27 Here’s a classic rash of a patient with rubella.

    00:32 But it’s not really the primary infection that we’re worried about in children.

    00:37 What we’re worried about is the other getting a primary infection while the infant is inside them.

    00:44 So if a mother acquires the disease while she’s pregnant, the infant can be born stillborn.

    00:53 Stillborn babies are reasonably common with congenital rubella.

    00:58 Or they may have a triad of symptoms.

    01:01 So the classic triad of rubella is cataracts, like we can see here, deafness and cardiac defects.

    01:10 So eyes, ears, and heart.

    01:13 In addition to this triad, infants may be born with blueberry muffin spots.

    01:19 This is a commonly tested question.

    01:22 These muffin spots are different than the rash I showed you in the previous patient.

    01:26 That was just acquired rubella.

    01:29 This is congenital rubella and they develop these blue lesions in their skin.

    01:35 These blue lesions are because there is actually extramedullar hematopoiesis going on in the skin in these infants.

    01:44 Let’s switch gears now to congenital CMV or cytomegalovirus.

    01:49 This the most common congenital infection in the United States.

    01:54 Fortunately, the majority are asymptomatic.

    01:57 But 10% will have symptoms at birth.

    02:00 This will present as prematurity, hepatosplenomegaly, being small for gestational age, having a small head, microcephaly, which is similar to toxo, or having seizures.

    02:12 They may also have late symptoms, which include hearing, vision loss, developmental delay or a seizure disorder.

    02:21 So early symptoms are fairly non-specific except they do have microcephaly and then later symptoms, they can develop hearing and vision loss, developmental delay and seizures.

    About the Lecture

    The lecture Congenital Rubella (German Measles) and Cytomegalovirus Infection (CMV) by Brian Alverson, MD is from the course Neonatology (Newborn Medicine).

    Included Quiz Questions

    1. Cataracts
    2. Deafness
    3. Cardiac defects
    4. Joint pain
    5. Epistaxis

    Author of lecture Congenital Rubella (German Measles) and Cytomegalovirus Infection (CMV)

     Brian Alverson, MD

    Brian Alverson, MD

    Customer reviews

    5,0 of 5 stars
    5 Stars
    4 Stars
    3 Stars
    2 Stars
    1  Star