So, now let's go on to the roseoloviruses.
Human herpes viruses 6 and 7
together can be acquired via saliva,
or via aerosols.
You're seeing a recurring theme here.
And here we have some infected lymphocytes,
which are just looking quite prominent
with cytoplasmic inclusions
in the image on the screen.
The clinical manifestations of these,
both HHV-6, human herpes virus 6,
and HHV-7 can cause roseola
or exanthem subitum.
Roseola has also been named sixth disease
because it was the disease associated
with the sixth named or discovered
human herpes virus.
Kind of makes sense.
Roseola is very common in pediatrics,
and those of you who are parents
have probably already experienced
this in your children.
will be 3 to, sometimes 5 days
of a very high fever
with extreme fussiness,
followed as the fever defervesces
with a diffuse,
faint, flat, macular rash, such as you
see in the picture on the right.
If you're like my daughter,
this will happen when you're
for Thanksgiving or some
other national holiday.
And the high fevers and extreme fussiness
will completely disrupt the weekend.
When you get home and put your child in
the bathtub is when the fevers are better.
The child is a happy Angel, and this
beautiful rash blossoms.
Human herpes virus 7, in addition,
can cause a whole
host of other things which
you see listed there.
So, an acute febrile respiratory disease,
which may or may not be
accompanied with rash,
sometimes gastrointestinal disturbances,
patients who undergo laboratory
testing may demonstrate
leukopenia, a low lymphocyte count.
Febrile seizures, because the height of
the fever and the rapid onset of the fever.
In fact, this applies to both
human herpes virus 6 and 7, and roseola,
the fever is so high and so extreme
that they are highly associated
with febrile seizures.
Back to just human herpes virus 7,
it can also set up a patient to
have a drug-induced
hypersensitivity syndrome, and the
drugs classically are antibiotics
or anti-epileptics, seizure medications.
Patients also with HHV-7 can have
central nervous system disease,
with primary seizures, and then
hepatitis, pityriasis, rosea, as
mentioned previously in this talk.