Roseolovirus (HHV-6 and HHV-7) – Herpesviruses

00:01 So, now let's go on to the roseoloviruses.

00:05 Human herpes viruses 6 and 7 together can be acquired via saliva, or via aerosols.

00:12 You're seeing a recurring theme here.

00:14 And here we have some infected lymphocytes, which are just looking quite prominent with cytoplasmic inclusions in the image on the screen.

00:23 The clinical manifestations of these, both HHV-6, human herpes virus 6, and HHV-7 can cause roseola or exanthem subitum.

00:35 Roseola has also been named sixth disease because it was the disease associated with the sixth named or discovered human herpes virus.

00:44 Kind of makes sense.

00:46 Roseola is very common in pediatrics, and those of you who are parents have probably already experienced this in your children.

00:54 Classic roseola will be 3 to, sometimes 5 days of a very high fever with extreme fussiness, followed as the fever defervesces with a diffuse, faint, flat, macular rash, such as you see in the picture on the right.

01:10 If you're like my daughter, this will happen when you're visiting grandparents for Thanksgiving or some other national holiday.

01:16 And the high fevers and extreme fussiness will completely disrupt the weekend.

01:21 When you get home and put your child in the bathtub is when the fevers are better.

01:26 The child is a happy Angel, and this beautiful rash blossoms.

01:30 Oh, joy.

01:31 Human herpes virus 7, in addition, can cause a whole host of other things which you see listed there.

01:37 So, an acute febrile respiratory disease, which may or may not be accompanied with rash, sometimes gastrointestinal disturbances, vomiting, diarrhea, patients who undergo laboratory testing may demonstrate leukopenia, a low lymphocyte count.

01:54 Febrile seizures, because the height of the fever and the rapid onset of the fever.

01:59 In fact, this applies to both human herpes virus 6 and 7, and roseola, the fever is so high and so extreme that they are highly associated with febrile seizures.

02:10 Back to just human herpes virus 7, it can also set up a patient to have a drug-induced hypersensitivity syndrome, and the drugs classically are antibiotics or anti-epileptics, seizure medications.

02:24 Patients also with HHV-7 can have central nervous system disease, so encephalopathy with primary seizures, and then hepatitis, pityriasis, rosea, as mentioned previously in this talk.