Roseolovirus (HHV-6 and HHV-7) – Herpesviruses

by Sean Elliott, MD

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    00:01 So, now let's go on to the roseoloviruses.

    00:05 Human herpes viruses 6 and 7 together can be acquired via saliva, or via aerosols.

    00:12 You're seeing a recurring theme here.

    00:14 And here we have some infected lymphocytes, which are just looking quite prominent with cytoplasmic inclusions in the image on the screen.

    00:23 The clinical manifestations of these, both HHV-6, human herpes virus 6, and HHV-7 can cause roseola or exanthem subitum.

    00:35 Roseola has also been named sixth disease because it was the disease associated with the sixth named or discovered human herpes virus.

    00:44 Kind of makes sense.

    00:46 Roseola is very common in pediatrics, and those of you who are parents have probably already experienced this in your children.

    00:54 Classic roseola will be 3 to, sometimes 5 days of a very high fever with extreme fussiness, followed as the fever defervesces with a diffuse, faint, flat, macular rash, such as you see in the picture on the right.

    01:10 If you're like my daughter, this will happen when you're visiting grandparents for Thanksgiving or some other national holiday.

    01:16 And the high fevers and extreme fussiness will completely disrupt the weekend.

    01:21 When you get home and put your child in the bathtub is when the fevers are better.

    01:26 The child is a happy Angel, and this beautiful rash blossoms.

    01:30 Oh, joy.

    01:31 Human herpes virus 7, in addition, can cause a whole host of other things which you see listed there.

    01:37 So, an acute febrile respiratory disease, which may or may not be accompanied with rash, sometimes gastrointestinal disturbances, vomiting, diarrhea, patients who undergo laboratory testing may demonstrate leukopenia, a low lymphocyte count.

    01:54 Febrile seizures, because the height of the fever and the rapid onset of the fever.

    01:59 In fact, this applies to both human herpes virus 6 and 7, and roseola, the fever is so high and so extreme that they are highly associated with febrile seizures.

    02:10 Back to just human herpes virus 7, it can also set up a patient to have a drug-induced hypersensitivity syndrome, and the drugs classically are antibiotics or anti-epileptics, seizure medications.

    02:24 Patients also with HHV-7 can have central nervous system disease, so encephalopathy with primary seizures, and then hepatitis, pityriasis, rosea, as mentioned previously in this talk.

    About the Lecture

    The lecture Roseolovirus (HHV-6 and HHV-7) – Herpesviruses by Sean Elliott, MD is from the course Viruses.

    Included Quiz Questions

    1. ...sixth disease
    2. ...seventh disease
    3. ...fifth disease
    4. ...third disease
    5. ...fourth disease
    1. Pityriasis rosea
    2. Pityriasis alba
    3. Pityriasis rubra pilaris
    4. Pityriasis versicolor
    5. Pityriasis amiantacea

    Author of lecture Roseolovirus (HHV-6 and HHV-7) – Herpesviruses

     Sean Elliott, MD

    Sean Elliott, MD

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