by Georgina Cornwall, PhD

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    00:01 Before we go there, let’s take a look at our ribosomes.

    00:03 Ribosome structure, we have reviewed in our lecture on cell structures, but we’ll go over some of that again.

    00:12 There are small and large subunits.

    00:16 The small subunit is generally involved in the decoding of the messenger RNA, sort of reading what’s on there.

    00:24 There’s lots of protein and lots of RNA in our ribosomes.

    00:30 The large subunit, having lots of RNA, is also involved in peptide bond formation of the growing amino acid chain.

    00:40 And I’ll show you how that works coming up here shortly.

    00:44 That large subunit contains the enzyme peptidyl transferase, which transfers peptides, so that’s a hint of what’s coming up.

    00:52 So the ribosome is a little bit different than polymerases.

    00:57 I had mentioned before that the 5’ end is the front end with the 5’ cap on the mRNA’s head, right? And that is the end that the ribosome begins reading at.

    01:10 So the ribosome will read from 5’ to 3’ in translating the messenger RNA into a polypeptide chain.

    01:20 So there are three sites on our ribosome.

    01:24 The A-site, the P-site, and the E-site.

    01:31 I named these the arrival site, the polypeptide site and the exit site.

    01:39 So A, P, and E.

    01:40 It also spells APE, but I like to remember them based on their functions.

    About the Lecture

    The lecture Ribosome by Georgina Cornwall, PhD is from the course Gene Expression.

    Included Quiz Questions

    1. E site ----- act as Peptidyl transferase enzyme
    2. Ribosome ----- protein synthesis factory
    3. Small ribosomal subunit ----- decode mRNA
    4. P site ----- bind to tRNA having growing polypeptide chain
    5. A site ----- Acceptor site for an incoming charged tRNA

    Author of lecture Ribosome

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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