00:01
So let's look a little more
deeply at each of these principles.
00:05
So respect for persons, as I said,
starts with voluntariness,
meaning that there's any freedom
from coercion or undue influence,
that the person is freely choosing
to be a research participant,
and that there's then being
informed consent process.
00:21
So this is allowing
the individual to control
whether or not they
want to enroll in research.
00:27
And they're basing
that on their own values,
their own interests,
their preferences and the information
that's been given to
them by the researcher.
00:36
Now, in some context,
there may be cultural mores
that would say a community
leader also has to give permission
for the members of that community
to participate in the research.
00:48
So you have to know
what the particular locale is
and what the culture is
to determine how you're
going to demonstrate
respect for persons.
00:59
It also means that those
that have diminished capacity,
or sometimes we
might even consider,
you know,
children as research participants,
they will need to have
someone to speak on their behalf.
01:08
So they need a proxy decision
maker to decide whether
or not the research is in
that person's best interests.
01:17
And, you know,
another aspect of respect for persons
and voluntariness is this
idea that research subjects
can decide to withdraw
from a study at any point
so they can decide up front
whether they want to join,
but once they're a
research participant,
once they're in the research,
they can decide
to withdraw that's
part of voluntariness.
01:37
Another aspect of respecting a
person as a research participant
is deciding how you're
going to share results
with them about what
you found in the research,
especially if it has implications
for their health or well-being.
01:51
There might be an
obligation of the researcher
as a sign of respect to
share results with that person.
01:58
So they can have
something that's actionable.
02:00
The core of respect for persons
is going to be informed consent.
02:04
So similar when we're
thinking about clinical medicine,
the need for a process
to give information
and have a person make
a decision for themselves,
that information
should be should
be given in
understandable language.
02:17
And when we're thinking
about research in particular,
the top of the list,
the thing that they need
to be clear about is
that this is research.
02:25
This is not clinical care.
02:27
There's a particular hypothesis,
there's a particular
research question.
02:32
That's the purpose
of their joining
this study is for research aims.
02:37
They need to understand what
the purpose of the research is
what you're trying to understand,
what the knowledge
that you're trying to seek
in the research study is,
what are going to be
the procedures involved,
especially from their perspective,
as a research participant,
what are the things
that they need to do
as a research participant.
02:57
They need to be aware
of the potential risks,
the potential benefits,
and whether there are alternatives
to their participation as
a research participant,
they might decide, well,
they just want to seek clinical care,
and not engage in this
clinical research project.
03:13
Another aspect of
informed consent,
so usually, we think about that,
you know, at the time of enrollment,
but another aspect is,
as the study is underway,
and the researchers are
learning new information,
there might be times where that
information becomes irrelevant
to that ongoing participation
by the research subject.
03:34
So that information also is part
of what's given to the person,
especially if it might be something
that affects their condition,
affects how the study design is,
they need to be given
that information in order
to consent to ongoing
participation or to say,
well, I need to seek medical
care for new information
that you've learned as
a result of the research.