Welcome to Pharmacology by Lecturio.
I'm Dr. Pravine Shukle.
We're going to be covering some reproductive pharmacology today.
Listen, this is a huge topic.
You can see all the different subtypes
and categories on the screen beside me.
The gonadal hormone antagonists and agonists
sometimes do the same thing
and sometimes they do the opposite thing of what you expect.
We're going to spend a lot of time in each section
and we're going to go over them in detail,
so that you understand them
and you feel confident answering questions on exams.
We're going to be talking about estrogens and anti-estrogens.
We’ll be talking about progestins and anti-progestins
and we're going to be talking about
androgens and anti-androgens.
With respect to the anti-estrogen medications,
there's a whole bunch of subtypes there.
There are the receptor antagonists.
There are aromatase inhibitors
and then there are GnRH agonists, like danazol,
and antagonists, which interestingly enough do the same thing.
Underneath the receptor antagonist section –
this is estrogen receptor antagonists –
we have full antagonists and we have selective antagonists.
With respect to the progestins,
we have actual progestin that we administer
and we have an anti-progestin called mifepristone.
With respect to the androgens,
we have a whole list of medications.
We have anti-androgens that are receptor antagonists.
We have 5-α-reductase inhibitors.
We have synthesis inhibitors.
And we have other ones such as the GnRH agonists and antagonists.
When we take a look at reproductive pharmacology,
just have a look at this diagram.
I won't go over it in detail now
because each section of this diagram
will be placed beside the specific area that we’re talking about.
This just gives us an overview.
So, have a look at it on your own time.
It's a very good diagram to understand how all of the drugs fit in.