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The lecture Renal Clearance – Elimination Kinetics by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics.
Which of the following is the correction factor used for females in the CockroftGault formula?
A 75yearsold schizophrenic patient is prescribed lithium by his doctor. His pharmacokinetic parameters are: 100 % renal excretion, half life of 27 hours, clearance of 1.8 L per hour , volume of distribution of 51 L, minimum effective concentration of 25mg per L and maximum toxic level of 63 mg per L. His renal failure has dropped to half the normal. His previous dose was 400 mg twice daily. What should be his new dose?
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