Receptors and Messengers

by Kevin Ahern, PhD

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    This picture depicts a hormone receptor in orange and a hormone in yellow that binds to it. Now as I said earlier, most hormone receptors are membrane bound, embedded in the membrane. And most steroid hormone receptors are found in the cytoplasm or nucleus. It’s the interaction of the hormone with the receptor that causes the signal which the hormone is communicating ultimately to be exerted inside of the cell. Now this simple figure schematically shows what’s happening. We can see on the left that the hormone is getting ready to bind to the receptor. And on the right we can see the hormone after it is bound to the receptor. On the outside part of the cell, which is the top layer here, that’s where the hormone is found, we see that there's a binding site for that hormone. And on the bottom side of the receptor which is the inside of the cell, we see that after the hormone binds, that part of the protein changes shape very slightly. Now very slight change in shape of that protein changes the interaction of that protein with molecules that are on the inside of the cell. So what we’re seeing here is the first step of communication, and we’re seeing how that communication actually ultimately will exert its effects. So this picture depicts two different ways in which signals can be communicated inside the cell. On the left we see steroid hormones, and as I said, steroid hormones are unusual in being able to navigate that lipid bilayer all by themselves. They get inside of the cytoplasm which is that middle layer that’s there. And you see that they bind to that purple colored molecule. That purple colored molecule is a steroid receptor floating around in the cytoplasm. When that...

    About the Lecture

    The lecture Receptors and Messengers by Kevin Ahern, PhD is from the course Hormones and Signal Transduction. It contains the following chapters:

    • Receptors
    • Receipt of Message
    • Second Messengers

    Included Quiz Questions

    1. They change shape on binding to their hormone.
    2. They are always membrane bound.
    3. They change shape on binding to another receptor.
    4. All of the answers are true.
    5. None of the answers are true.
    1. They are generally small molecules.
    2. They covalently modify proteins.
    3. They carry messages out of cells.
    4. All of the answers are true.
    5. None of the answers are true.

    Author of lecture Receptors and Messengers

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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    Very good!
    By Laura P. on 11. May 2017 for Receptors and Messengers

    Thank you Dr. Kevin Ahern!!! Sometimes you speak so fast, but these time was perfect :)