Quick Review: Systemic Sclerosis

by Stephen Holt, MD, MS

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    00:01 Alright, so let's do a quick review. We've got two questions here.

    00:04 As always, I'll ask a question, pause the screen, and unpause it when you're ready for the answer.

    00:08 All of the following are common manifestations of systemic sclerosis except? Alright, digital ulcers; that's part of calcinosis cutis and something we would look for the CREST syndrome.

    00:23 Myocardial fibrosis is a late manifestation of the diffused cutaneous type.

    00:28 Gastroparesis can also be present. Carpal tunnel syndrome also a feature.

    00:33 Erthema nodosum; not part of this disease.

    00:36 You would be looking for E nodosum in something like sarcoidosis but not systemic sclerosis.

    00:41 Next question, which of the following is strongly associated with CREST syndrome? Alright, ACE level; it's something we think about with sarcoidosis not with CREST syndrome.

    00:56 Next stop is the anti-centromere antibody and this is the classic antibody that we think of with limited cutaneous systemic sclerosis.

    01:04 Next stop the anti Scl-70 antibody or the antitopoisomerase 1 antibody is the antibody we think of with diffused cutaneous systemic sclerosis.

    01:15 Anti-double-stranded DNA is a characteristic feature of lupus.

    01:18 And the HLA-B27 allele is something that we see with our axial spondyloarthritides.

    01:24 Well, since limited cutaneous system sclerosis is typically manifested with the CREST syndrome, we know that our answer to this question is number two.

    01:33 And with that we've concluded our conversation about systemic sclerosis.

    About the Lecture

    The lecture Quick Review: Systemic Sclerosis by Stephen Holt, MD, MS is from the course Connective Tissue Diseases.

    Included Quiz Questions

    1. ...positive serology result for anticentromere antibodies.
    2. ...positive serology result for anti–Scl 70 antibodies.
    3. ...myocardial fibrosis.
    4. ...carpal tunnel syndrome.
    5. ...gastroparesis.

    Author of lecture Quick Review: Systemic Sclerosis

     Stephen Holt, MD, MS

    Stephen Holt, MD, MS

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