Quick Review: Systemic Sclerosis

00:01 Alright, so let's do a quick review. We've got two questions here.

00:04 As always, I'll ask a question, pause the screen, and unpause it when you're ready for the answer.

00:08 All of the following are common manifestations of systemic sclerosis except? Alright, digital ulcers; that's part of calcinosis cutis and something we would look for the CREST syndrome.

00:23 Myocardial fibrosis is a late manifestation of the diffused cutaneous type.

00:28 Gastroparesis can also be present. Carpal tunnel syndrome also a feature.

00:33 Erthema nodosum; not part of this disease.

00:36 You would be looking for E nodosum in something like sarcoidosis but not systemic sclerosis.

00:41 Next question, which of the following is strongly associated with CREST syndrome? Alright, ACE level; it's something we think about with sarcoidosis not with CREST syndrome.

00:56 Next stop is the anti-centromere antibody and this is the classic antibody that we think of with limited cutaneous systemic sclerosis.

01:04 Next stop the anti Scl-70 antibody or the antitopoisomerase 1 antibody is the antibody we think of with diffused cutaneous systemic sclerosis.

01:15 Anti-double-stranded DNA is a characteristic feature of lupus.

01:18 And the HLA-B27 allele is something that we see with our axial spondyloarthritides.

01:24 Well, since limited cutaneous system sclerosis is typically manifested with the CREST syndrome, we know that our answer to this question is number two.

01:33 And with that we've concluded our conversation about systemic sclerosis.