00:01 Alright, so let's do a quick review. We've got two questions here. 00:04 As always, I'll ask a question, pause the screen, and unpause it when you're ready for the answer. 00:08 All of the following are common manifestations of systemic sclerosis except? Alright, digital ulcers; that's part of calcinosis cutis and something we would look for the CREST syndrome. 00:23 Myocardial fibrosis is a late manifestation of the diffused cutaneous type. 00:28 Gastroparesis can also be present. Carpal tunnel syndrome also a feature. 00:33 Erthema nodosum; not part of this disease. 00:36 You would be looking for E nodosum in something like sarcoidosis but not systemic sclerosis. 00:41 Next question, which of the following is strongly associated with CREST syndrome? Alright, ACE level; it's something we think about with sarcoidosis not with CREST syndrome. 00:56 Next stop is the anti-centromere antibody and this is the classic antibody that we think of with limited cutaneous systemic sclerosis. 01:04 Next stop the anti Scl-70 antibody or the antitopoisomerase 1 antibody is the antibody we think of with diffused cutaneous systemic sclerosis. 01:15 Anti-double-stranded DNA is a characteristic feature of lupus. 01:18 And the HLA-B27 allele is something that we see with our axial spondyloarthritides. 01:24 Well, since limited cutaneous system sclerosis is typically manifested with the CREST syndrome, we know that our answer to this question is number two. 01:33 And with that we've concluded our conversation about systemic sclerosis.
The lecture Quick Review: Systemic Sclerosis by Stephen Holt, MD, MS is from the course Connective Tissue Diseases.
All of the following features are associated with diffuse cutaneous systemic sclerosis EXCEPT...?
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