Questions – Lipid Control

by Pravin Shukle, MD

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    Okay, let's move on to a question. The following will be effective in homozygous familial hypercholesterolemia except, colesevelam, mipomersen, ezetimibe, and rosuvastatin. Good for you, you chose rosuvastatin. Now this is a question that medical students are always getting wrong. They always get it wrong because they assume that rosuvastatin is really powerful. But remember statins, are definitely going to require aggresive normal LDL production. So let's move on to the second question. What is the mechanism of action of Ezetimibe? Is it A, a blockage of the enzyme that produces intracellular cholesterol. Is it B, increased synthesis of PCSK9. Is it C, increased uptake of luminal cholesterol in the blood stream or into the blood stream. Is it D, inhibition of intestinal cholesterol transport proteins. Or is it E, reduction of the calcium slow current. Good, you chose D. So D, inhibition of intestinal cholesterol transport proteins reduces the level LDL in the blood. A is incorrect because blockage of an enzyme that produces intracellular cholesterol, that's a statin. B. Increased synthesis of PCSK9, that's actually no drug. The PCSK9 inhibitors act as immune modulators or immunoglobulins that attach to PCSK9 and prevent it from doing it's job. C is wrong. Increase uptake of luminal cholesterol into the bloodstream. That almost does'nt even make any sense and E, reduction of the inward calcium slow current is wrong. They will do that to you because sometimes they will get you confused with a cardiac drug that sound similar. So pay attention to the drugs that you are using. Okay, let's go on to a question again. A 55-year old male has elevated LDL cholesterol. He was started on rosuvastatin 10mg daily. His current medications include perindopril for hypertension, aspirin, and fenofibrate for severe hypertriglyceridemia. What do you think the most...

    About the Lecture

    The lecture Questions – Lipid Control by Pravin Shukle, MD is from the course Cardiovascular Pharmacology. It contains the following chapters:

    • Question 1: Lipid Control
    • Question 2: Lipid Control
    • Case Study 1: Lipid Control

    Author of lecture Questions – Lipid Control

     Pravin Shukle, MD

    Pravin Shukle, MD

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