Pyruvate Oxidation

by Georgina Cornwall, PhD

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    00:00 Pyruvate oxidation occurs as the molecule passes across the mitochondrial membrane.

    00:07 So pyruvate needs to be oxidized a little further in order to pass across the mitochondrial membranes.

    00:13 You'll recall that glycolysis is happening out in the cytosol. It's important to keep these locations in line.

    00:20 We're tracking a 6 carbon glucose. As we go into pyruvate oxidation, this is the first time we're going to cleave a couple of carbons off.

    00:32 In cleaving carbons off, we will also get to pick up a couple more excited electrons with their hydrogen partners and take them off towards the dance.

    00:42 The first step in the game is where we have two pyruvate being converted into two acetyl coenzyme As.

    00:50 And then we also will see that the carbon dioxide comes off. So for each pyruvate, we have one carbon coming off, so one CO2.

    01:03 But we have two pyruvates because glucose had six carbons, and we're tracking carbons. It's important to do this accounting.

    01:10 So two 3 carbon pyruvates become to two 2 carbon acetyl CoAs and we lose two CO2s.

    01:19 We also produce a couple of full taxis. So NADs will come in, two of them, one per pyruvate, will come in and pick up two sets of electrons and two sets of protons and run them off to the prom or the exciting dance we're going to.

    About the Lecture

    The lecture Pyruvate Oxidation by Georgina Cornwall, PhD is from the course Energy, Enzymes and Metabolism.

    Included Quiz Questions

    1. 2, 2
    2. 6, 2
    3. 3, 6
    4. 5, 10
    5. 4, 4
    1. Mitochondria
    2. Cytoplasm
    3. Nucleoplasm
    4. Smooth endoplasmic reticulum
    5. Extracellular matrix

    Author of lecture Pyruvate Oxidation

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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    By William J. on 22. November 2017 for Pyruvate Oxidation

    I don't waste my time going to any biochemistry lectures at my medical school because I know that Dr Cornwall explains all of the content more clearly, in more depth, in less time. I always finish her lectures excited for the next one!

    By Lara G. on 05. November 2017 for Pyruvate Oxidation

    A great lecture. I am a high school student and i struggle with biology. I get a better explanation from your lectures and I am not even a native English speaker. Thank you so much!