Proto-Oncogenes & Mechanisms of Oncogene Activation – Carcinogenesis

by Carlo Raj, MD

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    Here we will take a look at proto-oncogenes. Always go back and take a look at that flow chart so that you know exactly as to where you are located. That is your roadmap to carcinogenesis. And at some point in time when you read a GPS you always want to kind of want to know where you began from and where you end up. And at this point we are looking at proto-oncogenes and before we get into actual carcinogenesis understand that proto-oncogenes are things that we require. For proper normal cellular growth. For example, as an embryo and a foetus our brain develops. We can't do that on our own. We need the help of proto-oncogenes. Now imagine that you have the development of cancer. This is unregulated, not supervised growth of cells. So what do you think happens to the proto-oncogenes. It gets mutated and then it becomes a oncogene. What's the name of a specialty that, maybe a clinician such as yourself in the future will go into? An oncologist. So here genes that actually form oncology or the practice of cancer. So what's the mechanism of action that you want to be familiar with. We will dive into great detail about RAS. And before we get into that I want to make sure that you understand a proper organization method that I will be setting up for you. You will be looking at growth factors and when the time is right I will talk to you about certain growth factors that are associated with certain cancers that you must know. Growth factors bind to please? Receptors, good. And those receptors will then communicate with whom? Signal transducers that are located where? On the inside aspect of your membrane. Where are you now? In the cytoplasm...

    About the Lecture

    The lecture Proto-Oncogenes & Mechanisms of Oncogene Activation – Carcinogenesis by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.

    Author of lecture Proto-Oncogenes & Mechanisms of Oncogene Activation – Carcinogenesis

     Carlo Raj, MD

    Carlo Raj, MD

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