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Proofread and Repair Mechanisms

by Georgina Cornwall, PhD
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    About the Lecture

    The lecture Proofread and Repair Mechanisms by Georgina Cornwall, PhD is from the course DNA Repair & Genetic Mutations.


    Included Quiz Questions

    1. The 3'-5' exonuclease activity of DNA polymerase III
    2. Photolyase activity
    3. Excision repair
    1. Mutagen can be any physical or chemical agent which brings the mutations in the DNA of an organism.
    2. Mutagens, the genotoxins, cause deleterious mutation during replication which leads to abnormal gene expression.
    3. Ionization radiation, UV light, reactive oxygen species, polycyclic aromatic hydrocarbons, intercalating agents, and transposons are associated with mutations in the DNA.
    4. Mutagens help the photolyase enzyme to chop off the damaged nucleotide sequences in the dsDNA.
    5. During DNA replication, the mutagen gets associated with DNA pol and helps in the recognization of wrongly incorporated nitrogenous bases.
    1. …is a visible light-dependent DNA repair enzyme specific to UV damaged DNA repair.
    2. …depends upon the presence of mutagen molecules to repair the damaged DNA.
    3. …works in association with transposons to repair damaged DNA.
    4. …creates thymine dimers in the DNA helix to stop the transposition of the transposons in a gene.
    5. …gets activated in the presence of UV light and chopped off the transposon DNA from the damaged gene.

    Author of lecture Proofread and Repair Mechanisms

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD


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    Helpful!
    By M.Baran Y. on 21. November 2017 for Proofread and Repair Mechanisms

    Very helpful on understanding the basics of the repair mechanisms.