00:01
So now let's look at
another electrolyte.
00:05
Potassium.
00:07
Potassium affects the
resting membrane potentials
in our neurons
and our muscle cells,
especially our
cardiac muscle cells.
00:16
An increase in the extracellular
fluid osmolality of potassium
would cause a decrease in our
resting membrane potential,
which would cause a depolarization
of the membrane,
which will lead to a reduced
excitability of the cells.
00:34
That's a bad thing.
00:36
Also, if there is
too little potassium,
in our extracellular fluid,
this could cause
a hyperpolarization
of our membrane potentials,
which could lead to
non-responsiveness
of our cardiac muscle cells.
00:52
Therefore, a disruption in our
potassium concentrations,
either hyper or hypo kalemia
in the heart
can interfere with the
electrical conduction
and can also lead to
sudden death.
01:08
Because of this,
our homeostasis of our
potassium levels is vital
for us to survive.
01:17
So, our potassium balance
is going to be controlled
in the cortical collecting ducts
of the kidneys
by regulating the amount
that is going to be secreted
into our filtrate.
01:31
If there is a high potassium content
in our extracellular fluids,
this is going to favor
the principal cells
of the collecting tubes
to secrete more potassium.
01:44
If, however, we have
low potassium levels,
this would cause
those principal cells
to reduce the secretion
of potassium to a minimum
so that we hold on
to as much potassium as possible.
01:59
Also, type A intercalated cells
are able to reabsorb
some of the potassium
that is left in our filtrate.
02:08
Our kidneys have a very limited
ability to retain potassium.
02:13
So most of the potassium
that makes it to the kidneys
is going to be lost in urine.
02:19
And this can sometimes
lead to a deficiency,
if we do not replace
our potassium in our diet.
02:27
This is why it's important
to eat bananas.
02:31
So the most important factor
that's going to affect
potassium secretion
is going to be its concentration in
our extracellular fluids.
02:42
A diet that is high in potassium
would lead to an increase
in the amount of potassium
found in our extracellular fluid.
02:52
Again, potassium entry
into the principal cells
of the collecting tubule
of the nephron
would lead to an increase in
the amount of potassium secreted,
and then released
into our urine.
03:06
If however, we have a
low potassium diet,
or if we are under a situation
where we have an
accelerated potassium loss,
this would reduce its secretion,
and promote its very limited
reabsorption.