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Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation

by Peter Delves, PhD
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    About the Lecture

    The lecture Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • Polymorphism of MHC
    • TCR Recognition of Peptide-MHC

    Included Quiz Questions

    1. ...a non-polymorphic part of MHC class I.
    2. ...a polymorphic part of MHC class I.
    3. ...a non-polymorphic part of MHC class II.
    4. ,,,a polymorphic part of MHC class II.
    5. ...a non-polymorphic part of both MHC class I and MHC class II.
    1. ...alpha-helices and beta-sheet floor of the peptide binding groove.
    2. ...beta-helices and alpha-sheet floor of the peptide binding groove.
    3. ...alpha-helices and beta-sheet floor of CD4 and CD8 binding sites.
    4. ...adjacent to non-polymorphic regions, where chemokines bind to the molecule.
    5. ...peptide binding groove where CD4 and CD8 bind.
    1. MHC class I, because MHC I binds to CD8 on cytotoxic T cells
    2. MHC class I, because MHC I binds to CD4 on cytotoxic T cells
    3. MHC class I, because MHC I binds to CD8 on helper T cells
    4. MHC class II, because MHC II binds to CD8 on cytotoxic T cells
    5. MHC class II, because MHC II binds to CD4 on Th2 cells
    1. ...the release of cytokines from Helper T cells or Regulatory T cells.
    2. ...the release of cytotoxic complement molecules which destroy immune response cells.
    3. ...the inactivation of T cell response when CD4 is bound to MHC II molecules in the presence of costimulation.
    4. ...the irreversible binding to T cells mediated by CD4.
    5. ...the ability to revert activated T cells back to naive T cells.

    Author of lecture Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation

     Peter Delves, PhD

    Peter Delves, PhD


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