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Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation

by Peter Delves, PhD
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    About the Lecture

    The lecture Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • Polymorphism of MHC
    • TCR Recognition of Peptide-MHC

    Included Quiz Questions

    1. A non-polymorphic part of MHC class I
    2. A polymorphic part of MHC class I
    3. A non-polymorphic part of MHC class II
    4. A polymorphic part of MHC class II
    5. A non-polymorphic part of both MHC class I and MHC class II
    1. Alpha-helices and beta-sheet floor of the peptide binding groove
    2. Peptide bind groove homodimers
    3. Alpha-helices and beta-sheet floor of CD4 and CD8 binding sites
    4. Adjacent to non-polymorphic regions, where chemokines bind to molecule
    5. Peptide binding groove where CD4 and CD8 bind
    1. MHC class I, CD8+ because MHC I binds to CD8+ and cytotoxic T cells without exception
    2. MHC class I, CD4+ because MHC I binds to CD+4 and cytotoxic T cells without exception
    3. MHC class I, CD8+ because MHC I binds to CD8+ and helper T cells without exception
    4. MHC class II, CD8+ because MHC II binds to CD8+ and cytotoxic T cells without exception
    5. MHC class II, CD4+ because MHC II binds to CD4+ and cytotoxic T cells without exception
    1. The release of cytokines from Helper T cells or Regulatory T cells
    2. The release of cytotoxic signals which destroy immune response cells
    3. The inactivation of T cell response when bound to MHC II molecules
    4. The irreversible binding to T cells mediated by CD4
    5. The ability to revert activated T cells back to naive T cells

    Author of lecture Polymorphism and TCR Recognition of Major Histocompatibility Complex – Antigen Processing and Presentation

     Peter Delves, PhD

    Peter Delves, PhD


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