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Polyketides – Lipids

by Kevin Ahern, PhD
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    00:00 tail that is shown on the left.

    00:01 The polyketides are another class of lipids that are very, very interesting. The polyketides are typically molecules that are made by organisms to protect themselves in the environment in which they reside and also to stake out environment for them. These molecules that you see on the screen are made by an organism called streptomyces. Erythromycin on the left is an antibiotic and it kills bacteria, it's very commonly used for this purpose.

    00:27 Natamycin on the other hand is an antifungal agent. Now each of these structures looks very, very complicated, but in fact they have very, very simple origins. Both of these molecules are made as by products and derivatives of the synthesis of fatty acids.

    00:45 This concludes what I want to say in this portion of the lecture about the structure of the basic lipids. There will be another lecture that will cover other structures of other lipids and also the way in which all of these molecules are metabolized.


    About the Lecture

    The lecture Polyketides – Lipids by Kevin Ahern, PhD is from the course Biochemistry: Basics.


    Included Quiz Questions

    1. Sphingomyelin is a polyketide which protects the nerve cells from the attack of parasites
    2. The polyketides are complex organic compounds falling into the category of lipids, which are synthesized via decarboxylative condensation of malonyl-CoA
    3. The erythromycin kills the bacteria present in the surroundings of the antibiotic producer actinobacterium streptomyces
    4. The polyketides are secondary metabolites, which give some survival advantage to the organism producing them over the others living in the same environmental conditions
    5. Many mycotoxins, bioactive compounds, produced by certain fungi are polyketides

    Author of lecture Polyketides – Lipids

     Kevin Ahern, PhD

    Kevin Ahern, PhD


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