00:00
So, let's start at the bottom for this case with polyarteritis nodosa. So polyarteritis nodosa,
again shown here on the right with multiple aneurysms and irregular constrictions, is a systemic
necrotizing vasculitis of medium-sized arteries in multiple organ systems. I'll also mention here
that many of these vasculitides are not exclusively involving medium vessels or small vessels or
large vessels. For the most part when we call something a small, medium, or large vessel vasculitis
we're just highlighting that most of the pathology is small or medium or large but a large vessel
vasculitides could also have some medium-sized arteries involved and a small vessel vasculitis
could have some medium vessels involved. So, just keep that in mind as we go through this. Next up
while polyarteritis nodosa like all of the vasculitides is idiopathic, we do know that it is
strongly associated with hepatitis B and hepatitis C so we have to keep that in mind. We were
told that she has a history of injection drug use with cocaine so perhaps she could've transmitted
HPV or HCV. Polyarteritis nodosa is characterized by segmental, transmural inflammation which
leads to luminal narrowing, thrombosis potentially, of course downstream ischemia as we've
talked about before, and aneurismal dilatation and that's of course what we're seeing in our
image. It's tissue necrosis that can lead to things like renal infarcts and other disease pathology.
01:30
What we're going to do now is take a brief detour from this slide just to talk about the different
ways that this segmental, transmural inflammation can manifest in various organs. We'll be
back to this one. So here's our list of the specific manifestations that we can see with
polyarteritis nodosa. First up on this skin exam you'll find palpable purpura, tender subcutaneous
nodules, and potentially livedo reticularis. This, if you perform a biopsy, will be associated with
some evidence of leukocytoclastic vasculitis which is a finding you'll see in a light of a different
vasculitides. The kidneys essentially can manifest with either renal artery aneurysms or potentially
renal infarcts if there's significant occlusion of the renal arteries, which of course you might
find on renal arteriography. In fact, new onset hypertension with an accompanying acute
kidney injury may be a significant clue to either renal artery aneurysms or renal infarction in
such patients. On the neurologic exam, you'll certainly find some peripheral nerve involvement
which could also be an indication of vasculitis involving the nerve's vascular system. That
condition is called mononeuritis and when you have multiple nerves involved you'd call it
mononeuritis multiplex and I'll remind you our patient seems to have an acute foot drop which
could be an indication of a mononeuritis. Next up, the gastrointestinal system. Like any artery
in the body, if the mesenteric arteries are a little bit occluded you can get intestinal ischemia.
02:59
So, mesenteric arteritis with intestinal angina would also be a feature that we'd be worried
about with polyarteritis nodosa amongst a number of other vasculitides and it sounds again
like that may be something that we're seeing in our patient. Okay, let's go back to that slide we
were looking at before. Now that we're back to the slide, we can briefly discuss the diagnosis
of polyarteritis nodosa. There's a lot of different manifestations that PAN can have that are
similar to the other vasculitides. So ultimately you're going to need a biopsy to make this
diagnosis. In contrast to the 3 other diagnoses that were on our list, the 3 other types of small
vessel vasculitis, this condition is going to be ANCA negative when you perform serologic testing.
03:41
Of course, a mesenteric arteriography might be helpful like the one shown here, that would be
a pretty strong clue for this diagnosis. Lastly, briefly talking about the treatment, you're
going to treat polyarteritis nodosa with steroids. You'll possibly add on cyclophosphamide in
certain cases best left to the discretion of a rheumatologist. And of course, if it turns out the
patient does have hepatitis B, you should probably go ahead and treat that too. One thing
we're going to see over time is that most of our vasculitides are going to be treated with
steroids plus or minus cyclophosphamide though there are some important cases where we would not
use those medications. Alright, so with all that in mind we've got an awful lot going for
polyarteritis nodosa. We'll need to get some more labs and imaging data before we draw any
conclusions, however. Of course, thinking back on the case though that history of asthma is
kind of odd but then again, you know, asthma is incredibly common and maybe there's nothing
to do with our patient's presentation. So we'll leave a question mark for PAN for now.