Plasmodium Malariae: Clinical Signs and Symptoms

by Vincent Racaniello, PhD

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    00:00 Some of the symptoms of malaria include fever and paroxysms of shaking chills and of course anemia, as the parasites multiply in red blood cells and destroy them. The paroxysms coincides with lysis of red blood cells, which of course is done to release the mereozoites.

    00:21 This causes the production of cytokines and the waves of fever so characteristic of the disease. Sometime the replication of the parasites within the blood cell is synchronized, so remember your body is full of many, many red blood cells, many of them can be infected with malaria parasites, and they can all mature at the same time and rupture at the same time in cycles, and a characteristic feature of malaria is these bouts of fever that occur in cycles, as all these red blood cells burst at more or less the same time. Other organs may also be involved in malaria besides the liver and the red blood cells, and this can result in hemolysis, which leads to icterus and jaundice, effects on the liver, an enlarged spleen, particularly as a consequence of trapping of infected red blood cells. Now normally a red blood cell is very deformable and it can move through tight spaces like capillaries and organs very readily. But when they are infected with malaria parasites they become less deformable, they get trapped in organs with small capillaries like the spleen and that causes disease.

    01:39 Now the four different species of malaria that I mentioned to you at the beginning of our talk differ in their virulence. All four of them are shown in their blood forms here.

    01:52 And depending on where you are what you get infected, you can have a somewhat different outcome. The long-term effects of repeated infections, which can happen because immunity is not protective, you may have learning deficits, reduced growth rate and in pregnant women, can lead to spontaneous abortion. So this is one of the tragedies of malaria in kids, young kids, who get repeatedly infected over and over, they feel miserable for months at a time, they can't learn properly and they can't go on to be productive adults in society.

    About the Lecture

    The lecture Plasmodium Malariae: Clinical Signs and Symptoms by Vincent Racaniello, PhD is from the course Parasites.

    Included Quiz Questions

    1. Red blood cells
    2. Lymphocytes
    3. Natural killer cells
    4. Macrophages
    5. Platelets
    1. Entrapment of RBCs
    2. Increase in growth hormone levels
    3. Increase in production of RBCs
    4. Abnormal tissue repair
    5. Increase in blood pressure due to low RBCs levels

    Author of lecture Plasmodium Malariae: Clinical Signs and Symptoms

     Vincent Racaniello, PhD

    Vincent Racaniello, PhD

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    good teachinig skills
    By Neuer N. on 31. October 2017 for Plasmodium Malariae: Clinical Signs and Symptoms

    the lecturer is very good in lecturing, i understand very well morethan in the class hall