Lymphadenopathy: Plasma Cell Neoplasms – White Blood Cell Pathology

by Carlo Raj, MD

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    In this topic, we’ll take a look at plasma cell neoplasms. And before we begin by looking at topics such as multiple myeloma, monoclonal gammopathy of undetermined significance and so forth, I want to make sure that you have a quick overview of the anatomy of immunoglobulin. And at this juncture, I’m not going to walk you through every component here. That is not my job. But it is absolutely important for me to have you focus on the light chain. So whenever we talk about plasma cell dyscrasias coming up, then we will be paying attention to light chains. And obviously, you’re referring to kappa and lambda light chain. And of the two light chains, you should definitely know that the kappa is increased much more so than lambda, 70% of the time. In addition, take a look at the heavy chain. And whenever you have heavy chain involvement, it would not be plasma cell dyscrasia. With heavy chain, these will be more of your translocation with chromosome 14, remember? 14. 8;14, 11;14, 14;18, right? Burkitt lymphoma, follicular lymphoma and your mantle cell. So what’s plasma cell? What’s happening? Well, this was B-cell once upon a time and it differentiated into a plasma cell. I want you to get in the habit of doing something for me. Plasma cell responsible for releasing and secreting what? Immunoglobulin. How many do you have? Five. G-A-M-E-D. You just spelled out gamed if that helps you, okay? Of all the immunoglobulin, which one comes out first? For any type of acute type of reaction or acute type of infection, IgM, right? Immediate, immediate. Of all the immunoglobulins, which one’s the biggest? IgM, pentamer, remember? Pentamer. IgM, it’s a pentamer. Keep those in mind. Now, the topics that we’ll get into and the types...

    About the Lecture

    The lecture Lymphadenopathy: Plasma Cell Neoplasms – White Blood Cell Pathology by Carlo Raj, MD is from the course Lymphadenopathy – White Blood Cell Pathology (WBC).

    Included Quiz Questions

    1. Burkitt lymphoma
    2. Smoldering myeloma
    3. Monocolonal gammopathy of unknown significance
    4. Multiple myeloma
    5. Solitary plasmacytoma of bone
    1. Monoclonal gammopathy of undetermined significance
    2. Plasmacytoma
    3. Multiple myeloma
    4. Lymphoplasmacytic lymphoma
    5. Isolated plasmacytoma of bone
    1. IgM
    2. IgE
    3. IgG
    4. IgA
    5. IgD

    Author of lecture Lymphadenopathy: Plasma Cell Neoplasms – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD

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