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00:01 Welcome to pharmacology by Lecturio. Today's topic is pharmacodynamics. 00:06 We are going to evaluate and see how drugs move through the body in pharmacodynamics. 00:12 Let's go over a couple of definitions. Excretion is the physical removal of drug from the body. 00:19 So for example, we're excreting drug into the urine, or into the bile, or exhaling inhalational drugs. 00:27 Elimination is a biochemical process without actual removal. So, eliminating a drug means that the drug may still be in the body, but you've rendered it somehow different through a biochemical process. 00:40 A receptor is a specific protein on or in the cell that binds to the drug to effect the change. 00:48 And effectors are molecules that effect a change as a result of the receptor and drug binding together. 00:55 So, a receptor binds to the drug, and effector molecule goes and does the job of the drug. 01:02 Affinity refers to the strength of the bond between a drug and receptor. 01:08 And selectivity refers to the proportion of or a preference of a receptor has for a particular drug. 01:15 It's usually compared to another similar kind of receptor, for example, we may have selectivity for the alpha 1 receptor versus the alpha 2 receptor, and the selectivity ratio may be 1000:1. 01:28 Specificity refers to the amount of preference a receptor has for a particular drug. 01:35 So, it's usually thought of as a comparator to another drug. So for example, one drug might be more specific to a receptor than a second drug. 01:47 Agonism refers to the ability to activate the mechanisms to cause an effect. 01:53 And antagonism is the ability to inhibit the mechanism to cause a biologic effect. 01:59 Efficacy refers to the maximum effect of a drug at its highest tolerated dose. 02:05 Well, potency is a measurement of the amount of drug needed to cause an effect. 02:10 So, a drug may have a high efficacy but a low potency.
About the Lecture
The lecture Introduction and Definitions of Pharmacodynamics – Pharmacodynamics by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics.
Included Quiz Questions
Which of the following terms refers to the ability of a drug to activate the mechanisms to cause a biologic effect?
- Agonism
- Affinity
- Efficacy
- Potency
Which of the following better describes the selectivity of a drug?
- The degree to which a drug acts on a given site relative to other sites
- The degree to which a drug acts on a given site relative to other drugs
Which of the following statements most accurately describes a drug with high potency and low efficacy?
- Requires a small dose but does not cause a strong biological effect.
- Requires a large dose and causes a strong biological effect.
- Requires a small dose but causes a strong biological effect.
- Requires a large dose and does not cause a strong biological effect.
Author of lecture Introduction and Definitions of Pharmacodynamics – Pharmacodynamics
Pravin Shukle, MD
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As a lecturer myself in another field you make something that is difficult easy to understand for learning transfer = A+ delivery thank you
5 STARS TO DR SHUKLE Because 1. He speaks clear American English. 2. Lectures are very visual, concise and substantial. 3. He behaves and dresses very professionally. 5. You learn a lot in little time with quizzes between lectures. 6. It's so much fun and easy.
