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Introduction and Definitions of Pharmacodynamics – Pharmacodynamics

by Pravin Shukle, MD

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    00:01 Welcome to pharmacology by Lecturio. Today's topic is pharmacodynamics.

    00:06 We are going to evaluate and see how drugs move through the body in pharmacodynamics.

    00:12 Let's go over a couple of definitions. Excretion is the physical removal of drug from the body.

    00:19 So for example, we're excreting drug into the urine, or into the bile, or exhaling inhalational drugs.

    00:27 Elimination is a biochemical process without actual removal. So, eliminating a drug means that the drug may still be in the body, but you've rendered it somehow different through a biochemical process.

    00:40 A receptor is a specific protein on or in the cell that binds to the drug to effect the change.

    00:48 And effectors are molecules that effect a change as a result of the receptor and drug binding together.

    00:55 So, a receptor binds to the drug, and effector molecule goes and does the job of the drug.

    01:02 Affinity refers to the strength of the bond between a drug and receptor.

    01:08 And selectivity refers to the proportion of or a preference of a receptor has for a particular drug.

    01:15 It's usually compared to another similar kind of receptor, for example, we may have selectivity for the alpha 1 receptor versus the alpha 2 receptor, and the selectivity ratio may be 1000:1.

    01:28 Specificity refers to the amount of preference a receptor has for a particular drug.

    01:35 So, it's usually thought of as a comparator to another drug. So for example, one drug might be more specific to a receptor than a second drug.

    01:47 Agonism refers to the ability to activate the mechanisms to cause an effect.

    01:53 And antagonism is the ability to inhibit the mechanism to cause a biologic effect.

    01:59 Efficacy refers to the maximum effect of a drug at its highest tolerated dose.

    02:05 Well, potency is a measurement of the amount of drug needed to cause an effect.

    02:10 So, a drug may have a high efficacy but a low potency.


    About the Lecture

    The lecture Introduction and Definitions of Pharmacodynamics – Pharmacodynamics by Pravin Shukle, MD is from the course Pharmacokinetics and Pharmacodynamics.


    Included Quiz Questions

    1. Agonism
    2. Affinity
    3. Efficacy
    4. Potency
    1. The degree to which a drug acts on a given site relative to other sites
    2. The degree to which a drug acts on a given site relative to other drugs
    1. Requires a small dose but does not cause a strong biological effect.
    2. Requires a large dose and causes a strong biological effect.
    3. Requires a small dose but causes a strong biological effect.
    4. Requires a large dose and does not cause a strong biological effect.

    Author of lecture Introduction and Definitions of Pharmacodynamics – Pharmacodynamics

     Pravin Shukle, MD

    Pravin Shukle, MD


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    A+ lecturer
    By Anneke A. on 24. November 2018 for Introduction and Definitions of Pharmacodynamics – Pharmacodynamics

    As a lecturer myself in another field you make something that is difficult easy to understand for learning transfer = A+ delivery thank you

     
    AMAZING! CONCISE AND VERY SUBSTANTIAL
    By Gerardo G. on 02. October 2017 for Introduction and Definitions of Pharmacodynamics – Pharmacodynamics

    5 STARS TO DR SHUKLE Because 1. He speaks clear American English. 2. Lectures are very visual, concise and substantial. 3. He behaves and dresses very professionally. 5. You learn a lot in little time with quizzes between lectures. 6. It's so much fun and easy.