00:01
Hi. This is the lecture on Pediatric Seizures, the most
common neurological
disorder of childhood. We're going to start by reviewing
some terms and concepts,
go into the etiology of seizures, the pathophysiology, the
classification, and the
diagnosis and treatment of them. Let's start, as always,
with the terms and
concepts. A seizure is basically a burst of uncontrolled
abnormal electrical activity
in the brain and it basically causes the body to make
movements that are
unconscious or unintended. A single seizure is not typically
considered epilepsy
or treated with antiepileptic drugs to stop seizures.
However, the most common
definition of epilepsy is 2 or more unprovoked seizures more
than
24 hours apart. Now, let's talk about the causes or etiology
of seizures. Anything
that causes some sort of insult or injury to the brain could
possibly cause a seizure.
01:05
So, starting with intracranial lesions or bleeding, febrile
seizures which we'll talk
about more in a moment, infections could cause a diseased
area of the brain, some
genetic disorders, metabolic disorders, and some toxic
ingestions. Alright, let's talk
a little bit more about how seizures occur. Basically, when
there is an area of the
brain that's not working correctly or is diseased or
injured, sometimes there's an
abnormal electrical activity that occurs all of a sudden. It
may be focal so basically
limited to a certain area of the brain or it may be more
generalized and occur in
various parts of the brain or in a larger area. Alright,
let's go over how seizures are
classified. Seizures are classified based on where they
originate in the brain which
means whether they're focal, limited to one area, whether
generalized or whether
there's an unknown onset or area of the brain affected. How
the person's level of
consciousness is affected and what types of movement occur
when they have a
seizure. Some of the movements that occur when a child or an
adult has a seizure
are tonic, clonic, absence, and atonic or akinetic. We're
going to go through each
of these. Tonic movement is a stiffening. It sometimes
happens by itself during a
seizure or sometimes it happens in addition to clonic
movements or shaking and
jerking. Tonic clonic movements are present in generalized
seizures and those are
the most common seizures and the most recognizable. Absence
seizures are when
somebody's space is off, does not lose consciousness
completely so they don't lose
muscle tone and like drop to the ground but they seem very
spacey and staring off
into one area for a while and you usually can't get their
attention. So these are the
seizures that probably cause the least degree of mental
status change most of the
time. And some people will have a seizure and just lose
muscle tone completely
and drop to the ground, but not have any kind of dramatic
movements. So, this is
called atonic or akinetic. A means lack of or absence of.
Alright, let's talk a little
bit about pediatric versus adult seizures. In the infant,
seizures can be very very
subtle and easy to miss. In fact, some infants will have
seizures at home for a good
while before the caregivers realize that that's what's
happening. They may not
realize it at all and just bring the infant into the
hospital to the emergency
department because they're acting odd or they can't get them
to feed. Children and
adults present similarly when they have seizures. Those
seizures are classified in
the same way, the movements are pretty much the same. The
basic rule of thumb
as with most things in pediatric assessment that the younger
the child especially the
younger the infant, the more subtle signs and symptoms are
including signs and
symptoms of seizures. In the neonate and young infant
especially, seizures no
matter where they occur in the brain or where they originate
from in the brain may
cause limited movements that are seen as being seizure
activity or possible seizure
activity. A lot of times they're in the face. So they might
be limited to eye
deviation, so the eyes may kind of just keep going to one
side over and over
repeatedly and it kind of looks like they're doing it
without intending to. Lip
smacking is another common way they present with a seizure
and sometimes they
have nystagmus which is like a vibration of the eye that
keeps going, it's kind of
rhythmic vibration that repeats. If the infant is
hospitalized or if the child is
hospitalized and they're being monitored and you're watching
their vital signs
when they have a seizure, they'll usually spike their heart
rate up. Their respiratory
rate will usually also go up a little bit at least and their
breathing pattern will be
irregular. Infantile spasms are really scary types of
seizures that are also difficult to
identify. Basically they look like the infant is startling,
so they usually throw their
limbs back. It doesn't usually last very long, but sometimes
it will repeat over and
over. Some of that really needs to be caught and identified
so it can be treated. So
basically it's the most common epilepsy of infancy. Its peak
onset is around 4-8
months and this makes it even tougher because they're likely
to get startled by
that age anyway by things like loud noises and that kind of
thing. It's very poorly
understood as far as what causes it and it usually leads to
cognitive impairment
especially if it's not caught because seizures, I mean even
though temporary quick
seizures can be benign and not cause any kind of damage. If
they repeat and repeat
and repeat, it can be hard on the brain and also cause
things like irregular
breathing, which can lead to further damage. Children deal
with something special
especially unique type of seizure called febrile seizures
that can be really
misunderstood quite often, so I'm going to give you a couple
points that might be
helpful. Basically, when a child has a febrile seizure, it
means that their brain is
just firing in a weird way real quickly in response to the
fever and those specific
thing that causes the febrile seizures is just a quick spike
in the temperature. A lot
of people think that it's the level of temperature, but it's
really not. It has to do with
how quickly it spikes. So, we may not even be able to
control them honestly, but
some children are just prone to this and usually the good
news is they're not usually
dangerous at all, they usually resolve very quickly on their
own and then very few
of these children go on to develop epilepsy, in fact less
than about 5%.