00:01
A diagnosis of asthma can
sometimes go beyond symptoms,
such as coughing, chest
tightness, wheezing, and dyspnea.
00:08
It can go even beyond those
signs and symptoms
that worsen at night and
improve with treatment.
00:13
Diagnosis may require certain tests,
including pulmonary function tests,
or PFTs, and peak expiratory
flow, or PEF measurements.
00:22
Asthma symptoms can be reversed
by rapid-acting beta agonist,
such as albuterol, and they can
be measured by spirometry.
00:29
A bronchial challenge
test is a medical test
used to assist in the diagnosis of asthma.
00:35
So, pulmonary function tests.
00:36
These are also known as spirometry,
and these measure the airflow
and the lung volumes
during a forced expiratory
maneuver from full inspiration.
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Spirometry can help the
clinician assess lung function
by measuring the total volume of air
that the patient can expel from the
lungs after a maximal inhalation.
00:53
And it can also be used to see if
airway constriction can be reversed,
and this is called reversibility testing.
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Think of an 8-lane highway
that's being squished down
and reduced into 4 lanes
due to road construction.
01:06
The traffic is going to take a lot longer
to travel through that stretch of highway.
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In the same way, if your airway is narrower
and narrower and narrower than normal,
it will take you longer to
empty your lungs of air.
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It can also compare that result to how
much air you breathed out altogether,
and this ratio tells how much
your airways are blocked.
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So, asthma, it's an obstructive
breathing disorder.
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This means that the air flows out of
your lungs more slowly than it should.
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The patients will wear a nose clip
to control their nasal air movement.
01:36
And this spirometry is going to
record the entire breathing loop;
the inspiration and the expiration.
01:42
And again, this is useful
for reversibility testing.
01:45
Usually, medication is more
effective if you have asthma
because the airways are going
to react to the medication.
01:53
In pulmonary function testing, we're
looking at a few different values.
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The first is the forced vital
capacity, or the FVC.
02:00
This is the volume of air which is forcibly
and maximally exhaled out of the lungs
after taking the deepest breath possible.
02:07
The next is the forced expiratory
volume in 1 second, or the FEV1.
02:12
And this is the volume of air which can
be forcibly exhaled from the lungs
in the first second of a
forced expiratory maneuver.
02:19
The last is a ratio and this indicates
what percentage of the total
FVC is expelled from the lungs
during the first second of
total forced exhalation.
02:29
Now, let's talk about peak expiratory
flow tests, also known as peak flows.
02:34
A peak flow meter is an
inexpensive, portable,
handheld device for those with asthma
that is used to measure how well the
air moves in and out of the lungs.
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This measure is called a
peak expiratory flow.
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If a patient tracks their peak flows
every day at the same time every day,
the tool can be really useful to predict
when a narrowing might be
happening or a prodrome.
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Sometimes, this can happen hours or days
before their asthma symptoms present
and a patient can be proactive
about their treatment measures.
03:04
Usually, a patient will measure their
peak flow at least once a day,
usually in the morning before they
take their asthma medications.
03:10
To perform this test well and consistently,
the patient needs to have good
and consistent technique.
03:16
Before the patient blows into the meter,
they will want to be able to
fully expand their chest cavity,
so they need to stand up.
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Next, they'll take a full deep breath.
03:27
They'll close their lips
around the mouthpiece
and blow out hard and fast in a single blow.
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Now, in a patient with asthma,
this can really trigger a cough
and assure your patient that's okay.
03:36
They can recover between the attempts.
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Your patient's going to repeat this about
3 times and record the highest number
and that's the peak flow that
they're going to use for that day.
03:46
Finally, let's talk about the
bronchial challenge test.
03:49
This is where the clinician tries to see
if they can cause an asthma
attack in a patient,
and this can assist in the diagnosis.
03:57
During this test, the patient
is going to breathe
in nebulized methacoline
or histamine.
04:02
So this test can be called a methacoline
challenge or a histamine challenge.
04:06
In a controlled clinical environment,
the patient's going to inhale methacoline
aerosols in increasing concentrations.
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Various protocols can be used.
04:14
Spirometry is performed before
and after each dose,
and the results are reported
as a decrease in FEV1
from baseline for each step of the protocol.
04:24
Methacoline is going to irritate the airway
and cause a narrowing in susceptible people.
04:28
And this can cause a severe
bronchoconstriction,
hyperinflation, and severe coughing.
04:34
The patient's airway is basically
being forced into an asthma attack.
04:39
The challenge is considered
positive if the methacoline causes
a 20% or greater decrease in the
patient's breathing ability
when compared to their baseline.
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A positive test suggests that
the airways are reactive
and a diagnosis of asthma
should be considered.
04:53
A negative test means the
diagnosis of asthma is unlikely.
04:57
The procedure is generally well-tolerated
and respiratory symptoms in patients
who react to the methacoline
typically reverse promptly
in response to bronchodilators.
05:06
While, this is a pretty common test,
it should be performed in a setting
equipped to deal with acute bronchospasm,
and with personnel trained in resuscitation.
05:14
Informed consent should be obtained
and recorded in the medical record
after a detailed explanation of the risks
and benefits of this
procedure are discussed.