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Parkinsonism and Treatment of Parkinson's Disease

by Georgina Cornwall, PhD
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    The lecture Parkinsonism and Treatment of Parkinson's Disease by Georgina Cornwall, PhD is from the course Aging.


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    1. It blocks the peripheral conversion of Levodopa to dopamine, norepinephrine, and epinephrine, thus decreasing adverse side effects of Levodopa.
    2. It acts as a direct dopamine agonist, at the cost of increasing side effects of Levodopa.
    3. It is required for the transport of Levodopa across the blood-brain barrier.
    4. It acts as a direct dopamine antagonist peripherally, thus decreasing adverse side effects of Levodopa.
    5. It is a catalyst for the conversion of levodopa to dopamine once it crosses the blood-brain barrier.
    1. Neither DBS nor dopaminergic/dopa-decarboxylase inhibitor therapies are definitive, but both provided limited symptomatic relief of the disease.
    2. Both DBS and dopaminergic/dopa-decarboxylase inhibitor therapies are definitive treatments for the disease.
    3. DBS is a definitive treatment for Parkinson's disease, while dopaminergic/dopa-decarboxylase inhibitor medication is simply for symptomatic relief.
    4. Both DBS and dopaminergic/dopa-decarboxylase inhibitor stimulate the release of dopamine from neurons in the substantia nigra.
    5. DBS has far more peripheral side effects than dopaminergic/dopa-decarboxylase inhibitor medical therapy.
    1. Parkinson's disease
    2. Brain injury
    3. MTPT contiminant in heroin
    4. Wilson's disease
    5. Progressive supranuclear palsy

    Author of lecture Parkinsonism and Treatment of Parkinson's Disease

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD


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