Paraneoplastic Syndromes – Carcinogenesis

by Carlo Raj, MD

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    Our topic now brings us to paraneoplastic syndromes and the different times in which you would expect to see certain syndromes and the associated cancer. Our first paraneoplastic syndrome will be acanthosis nigricans. Acanthosis nigricans means thickening of the keratinocyte giving it thus a dark colour. You might find this underneath the armpit or maybe the back of the neck and you should be thinking about maybe pancreatic or gastric adenocarcinoma. A topic here, this patient "Hey Doc, wake up in the mornning and I feel a little tired. Takes me a while to get going. 5, 6 o'clock in the evening I feel great. I wish my work day actually started at 5pm." In this patient, as the day wears on, he or she gets stronger. Not myasthenia gravis, the opposite. This is Eaton-Lambert myasthenic syndrome. Associations, small cell lung cancer. With small cell, we will take a look at 3 different associations. This is one of them. So what is Eaton-Lambert and what does it do? If you remember correctly from your Immunology, that you would have your immunoglobulin and autoantibodies. That are then attacking instead of acetylcholine receptors, they are attacking the calcium channels. Now I need you to picture this. Picture neuromuscular junction. Are you picturing it? Neuromuscular junction. Normally you would release what from the pre-synaptic terminal. Acetylcholine. What does it then bind to the post-synaptic terminal? Acetylcholine receptors. No problem there. What caused the fusion of your vesicle to the membrane in the pre-synaptic terminal. A trigger would be voltage gated calcium channels. Voltage gated calcium channels. These are the channels that are then being attacked by auto antibodies. So if the voltage gated calcium channels are dead, the patient wakes up in the morning, does'nt feel that great. Dr. Raj but how are...

    About the Lecture

    The lecture Paraneoplastic Syndromes – Carcinogenesis by Carlo Raj, MD is from the course Cellular Pathology: Basic Principles.

    Included Quiz Questions

    1. Stomach cancer
    2. Small cell carcinoma of the lung
    3. Pancreatic carcinoma
    4. Bronchogenic carcinoma
    5. Colorectal carcinoma
    1. Auto-antibodies to calcium channels
    2. Overproduction of clotting factors
    3. Hyperkeratosis
    4. Increased deposition of bone at distal phalanges
    5. Endocarditis
    1. Mucus secreting pancreatic carcinoma
    2. Stomach cancer
    3. Bronchogenic carcinoma
    4. Small cell carcinoma of the lung
    5. Hereditary colorectal carcinoma

    Author of lecture Paraneoplastic Syndromes – Carcinogenesis

     Carlo Raj, MD

    Carlo Raj, MD

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