Overview of Membranoproliferative Glomerulonephritis (MPGN)

by Carlo Raj, MD

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    00:01 Continuing our discussion of nephrotic, students tend to either forget or put things together and confuse themselves further with the membranous glomerulonephritis versus membranoproliferative glomerulonephritis.

    00:16 Our discussion previously under membranous glomerulonephritis, commonly found in adult Caucasian males approximately 40 years of age.

    00:25 Common cause of nephrotic in adult.

    00:28 With membranous, remember that it was a membrane involved and you also had what kind of deposit? A subepithelial deposit.

    00:35 Other causes that we also saw with it included your prescription drugs or drugs such as NSAIDS, penicillamine, or captopril.

    00:45 Now, with membranoproliferative, things get a little bit more interesting and whenever I say that, you know that it’s going to get really fascinating actually.

    00:54 So DPGN/MPGN, I’ll put these together here.

    00:57 And the reason I say that is DPGN which is commonly found with SLE induced type of DPGN or should I say DPGN is the most common type of SLE induced kidney damage had both nephritic and nephrotic type of signs and symptoms, didn’t it? MPGN both have PGN in them, MPGN/DPGN will once again have nephritic and nephrotic signs in them.

    01:21 What we’ll do also is the fact that we’ll take MPGN.

    01:24 Now, I’m gonna walk you through current day classification because it is a lot simpler, it’s a lot more straightforward and you’re not sitting there memorizing things.

    01:32 Hence, the algorithm and flow chart that we’ll take a look at here.

    01:36 It is imperative that you know this first.

    01:39 Once you do so, then you can see as to how easy it is for you to distinguish between MPGN type I and MPGN type II.

    01:47 Are we clear before we move on? Otherwise, repeat what I just said so that you clearly understand what this flow chart is about.

    About the Lecture

    The lecture Overview of Membranoproliferative Glomerulonephritis (MPGN) by Carlo Raj, MD is from the course Glomerulonephritis.

    Author of lecture Overview of Membranoproliferative Glomerulonephritis (MPGN)

     Carlo Raj, MD

    Carlo Raj, MD

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