00:00
So what's the outcome? Well if you have non-resistant
tuberculosis of a 100 cases you can expect
90 to 95% of patients can be cured, so it's
a very good outcome in most patients. And people
should not really die of tuberculosis, and
that only really happens if they have resistant
disease or if the diagnosis is made late because
the patient presents very late, or they have
the more severe forms such as Meningitis or
miliary tuberculosis.
00:30
There is a problem with TB and that once you
have had tuberculosis it can cause a lot of
lung damage. Now this normally happens in
people who have not been treated quickly or
effectively. So this is not a common complication
in the West but it's very common in people
who are born abroad. And the extensive lung
tuberculosis will leave extensive lung fibrosis
and that can have quite marked complications.
You get poor lung function because there will
be extensive pleural thickening around the
lung and also there seems to be a degree of
airways obstruction associated with extensive
tuberculosis. You can get cavities formed
by the tuberculosis, and those persist after
the bug has been killed and the patient is
healed of TB, and those cavities have been
colonized by fungi to cause mycetoma and that
might cause hemoptysis, and sometimes it
causes major hemoptysis. And often in the
areas of lung which have been particularly
affected by tuberculosis you get bronchiectasis,
and in my bronchiectasis's clinic, about
5% of the patients had previous tuberculosis
causing their disease and they present with
recurrent bacterial infections of the lung.
01:38
So this is a chest X-ray of somebody who had
tuberculosis when they were much younger.
01:44
And you can see there is an extensive scar occurring
on the right hand side and the right hemi diaphragm
is raised and that reflects, the fact that the right lung is much smaller than it should be.
01:53
And that's partly because
of the scarring within the lung but it's also
because there is a layer of pleural thickening
around the outside the lung, gripping it,
stopping it from being able to expand.
02:03
In addition, the right lung has quite a lot of scarring
in the apices and if you do a CT scan you
will see that there is quite a marked areas
of bronchiectasis and the occasional small
cavities in that area as well. And this is
a very classic situation that occurs with
people who have had an extensive case of pulmonary
tuberculosis when they are younger, and leads
to chronic lung disease and this patient has
respiratory failure as a consequence of this,
with type two restrictive failure even when
he is well.