Let's wrap up this series.
Opioids are drugs that act on the opioid receptors primarily
the mu and kappa as agonists, partial agonist or
Morphine is the “gold standard” for opioid agonist and is
used as a standard
to measure the potency of newer opioids.
Opioids can cause respiratory depression, let me pause right
That’s one of the number one takeaway you need from this
Opioids cause respiratory depression so you want to use them
with extreme caution
with other CNS depressant medications
and you want to educate your patients that they should never
be taken with alcohol.
Now opioids also cause some other uncomfortable things like
constipation, urinary retention,
orthostatic hypotension, really upset stomach and vomiting,
and elevated ICP.
Neonates, and infants and the elderly are particularly
sensitive to the effect of the opioids
so use them with extreme caution and consultation with the
health care provider.
Tolerance to opioids can develop with extended use and
opioid should be weaned
versus stopped abruptly so that your patients don’t
Fentanyl is up to 100x more potent than morphine and is
available in four different types of routes.
Remember Meperidine is no longer considered a first line
because of the risk of seizures if it’s used for greater
than 48 hours.
Oxycodone and hydrocodone all have similar pain relief
Thank you for watching out video today.