Oncogenes and Tumor Suppressor Genes: Review

by Georgina Cornwall, PhD

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    A quick review, we certainly covered this in the cell and molecular biology course. We have oncogenes and proto-oncogenes. Oncogenes are those that can potentially become cancerous or they will cause a cell to become cancerous. Then we have proto-oncogenes. Those are the genes before they’ve become oncogenes. A proto-oncogene is an early oncogene that has not yet caused a mutation that results in cancer. So, p53 was a classic example of a proto-oncogene that could mutate and become an oncogene and thus be cancer-causing. There are many genes involved in growth factor receptors as well as proteins in signal transduction pathways, the G-protein-coupled receptors, so on and so forth. Then the thing is with the sequencing of the genome, not only are we looking at what these expressed phenotype genes do but we also are now able to get a much closer look on what each of the regulatory pieces of the genome do also. So, as with other fields of genetics, the more we learn, the more there is to discover in essence as we go deeper and deeper into our understanding of the various pieces of the genome. Tumor suppressor genes, some that we have covered that are important for you to know for your exams are involved in preventing proliferation of mutated cells in their regular roles. That’s the whole meaning of tumor suppressor. In their functional form, they suppress development of a tumor by programming a cell for apoptosis, let’s say. So, p53 was one of those and the Rb protein as well as BRCA1 and BRCA2. Remember that Rb was the first one that we discovered. BRCA1 and BRCA2 are also tumor suppressor genes that are involved in breast cancer. They’re two that we have characterized fairly well, not to say that they are...

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    The lecture Oncogenes and Tumor Suppressor Genes: Review by Georgina Cornwall, PhD is from the course Population Genetics.

    Author of lecture Oncogenes and Tumor Suppressor Genes: Review

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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