00:00
Right, moving on to another sleep related
disorder, called obesity hyperventilation syndrome.
00:06
This is an increasingly common problem. The
pathogenesis of this disease is not terribly
clear, essentially the obesity results in reduced
chest wall movements and restrictive lung
function, and this seems to have a knock on
effect on the central control of ventilations,
so that as a consequence of the problems of
actually moving the lungs during respiration.
00:31
The brain decides to hyperventilate, it doesn't
seem entirely logical why this may happen,
but this is exactly what happens. The brain
signals for ventilation are turned down and
the consequences of that is that you end up
with hypoventilation, hypercapnia, type II
respiratory failure, and this is a vicious
circle. Because one of the problems of a high
PaCO2, raised carbon dioxide levels is that
CO2 in itself is a narcotic, and will, if
it is high enough, turn down ventilation because
of its central effects on the brain.
01:05
And these patients present with acute or chronic
type II respiratory failure, pulmonary hypertension
and cor pulmonale, the sort of problems that
we've discussed already.
01:14
It's actually obesity hyperventilation syndrome
is frequently misdiagnosed as either COPD
or OSA, other potential causes of type II
respiratory failure, the prevalence is not
really known but is very much related to obesity,
so it’s a very high body mass index and
it seems to be more specifically a problem
of women than necessarily men. Solicited drugs
exaggerate the problem and similar to obstructive
sleep apnea, it will present with daytime
hypersomnolence, but more marked problems,
the patient will be confused, cor pulmonale
is common, and is probably, in fact the second
commonest cause of admissions to hospitals
with acute hypercapnia, the first commonest
being COPD.
01:57
Sleep studies are used to show the overnight
hypoventilation that is occurring; you need
the blood gases to identify their respiratory
failure. The lung function tests show restrictive
changes due to the obesity and in the chest X
ray actually the lungs will look normal and
you may want to echo and ECG to look for cor
pulmonale.
02:16
Treatment is very difficult, essentially weight
loss, weight loss and weight loss, but that's
obviously very hard to achieve, Bariatric surgery
can be very helpful in those circumstances.
02:26
And the patient may need some form of ventilatory
support long-term, oxygen and often actually,
they need noninvasive ventilation as a long-term
treatment. The treatment for acute presentations,
this is type II respiratory failures, so it's
controlled oxygen, nasal ventilation, treatment
of the cor pulmonale, getting rid of the distal
oedema with diuretics etc.