pneumonia, what is this?
Well for the most part, it's
the histopathologic process
associated with many of your connective
tissue diseases or disorders
What is this referring to?
SLE being the most common.
Okay, so everything
that we're doing here,
with any autoimmune or connective tissue
disease is then causing damage to the lung
Where most likely? interstitial.
We will then call this
histopathologically what? nonspecific.
Okay, SLE being the most common,
also seen in individuals with
autoantibodies in general
but not clearly defined as being
connective tissue disease but notice such
so some of these that we'll take
a look at in this lecture series
are issues such as SLE.
So what does that mean
to you in terms of labs?
Oh, positive ANA. Oh, positive anti-Smith
which is a little bit more specific
Seen also in drug-induced.
if there is a patient that requires
an anti-neoplastic, or whatnot.
and at this point goes on to develop
a restrictive lung disease type,
then this will be more or less
your nonspecific type of findings
More frequent in younger patients, females
compared to usual interstitial pneumonitis
That usual interstitial pneumonitis was the
pathologic diagnosis that you found with
Idiopathic pulmonary fibrosis which
is a chronic type of fibrosis,
more frequent in
steroid-responsive than UIP
Rememeber in chronic fibrosis,
you'll have many of those underlying
disorders that you might have
and recurrent, recurrent , recurrent
bouts and damage to the lung
resulting in fibrosis.
And with that type of fibrosis,
very unlikely that it will then
respond to an anti-inflammatory.
However if it's a nonspecific type, well
you'd find maybe a little bit of curbing
of the symptoms of a patient
upon administration of steroids
Now, what are we looking at here
histopathologically? Pay attention.
The path shows patchy inflammation
however, you do not have
the abundance of fibroblast like we had
seen with usual interstitial pneumonitis.
Once again, in usual interstitial
idiopathic pulmonary fibrosis
clinically is what it's diagnosed as.
You would find lots of fibrosis deposition
hence we talked about the honeycomb
We also referred to well fibroblast
coming in laying down that collagen here.
However, if it's nonspecific
understand that you'd find patchy
type of inflammation overall
however fibroblast presence and collagen
deposition are less pronounced compared to UIP,
with areas of patchy inflammation
and relatively preserved lung architecture.