Non-Alcoholic Steatohepatitis (NASH)

by Carlo Raj, MD

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    Let's talk about a very important liver manifestation that you want to keep in mind in general population. The topic is Non-Alcoholic Fatty Liver Disease. And under Non-Alcoholic Fatty Liver Disease, I want you to focus upon the dreaded NASH or Non-Alcoholic Steatotic Hepatitis (NASH). To briefly summarize all the different classes of liver disease, from this point onwards, whenever you're dealing with liver issues in medicine, have a huge list of differentials. Including auto-immune causes such as Auto-immune hepatitis. Other auto-immune diseases that may cause liver disease including Primary Biliary Cirrhosis, Primary Cirrhosis Cholangitis. Then go into viral hepatitis. Think about alcoholic hepatitis and then here the most common cause of abnormal liver function test in general population is this; Once again the patient, not necessarily an alcoholic or even causing or the alcohol causing liver damage. In United States, obesity is an issue. When obesity is kicking in, then you know that you have a patient that insulin resistant and so therefore, is suffering from Hyperglycemia. Hypertension is an issue. And in addition to that, with all of that Hypertriglyceride or hyperlipidemia, which may then accummulate in the liver, we call this Non-Alcoholic Steato. What's Steato mean? Fat. Where are you? In the liver. So therefore, you call this Non-Alcoholic Steato Hepatitis. Histologically similar to very much, now which component of alcoholic liver disease? The fatty change. Alright, Steatotic Hepatitis. However here, the damage to liver is not being caused by alcohol. I wish to emphasize that over and over again and the umbrella or the canvas of diagnosis is Non-Alcoholic Fatty Liver disease. Under that, I'm having you focus on Non-Alcoholic Steatotic Hepatitis because this is the one that is going to give you clinical presentation. Thus, this is the one that you will be asked about...

    About the Lecture

    The lecture Non-Alcoholic Steatohepatitis (NASH) by Carlo Raj, MD is from the course Cirrhosis – Liver Diseases.

    Included Quiz Questions

    1. Chamomile tea
    2. Obesity
    3. Diabetes
    4. Total parenteral nutrition
    5. Drugs
    1. Hypertriglyceridemia
    2. Hypernatremia
    3. Hyperprotienemia
    4. Hypoglycemia
    5. Hypertension
    1. Extrahepatic cholestasis
    2. Mallory bodies
    3. Lymphocytic infiltrate
    4. Fat accumulation
    5. Ballooning degeneration

    Author of lecture Non-Alcoholic Steatohepatitis (NASH)

     Carlo Raj, MD

    Carlo Raj, MD

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