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Quantitative WBC Disorders: Neutrophilic Leukocytosis – White Blood Cell Pathology

by Carlo Raj, MD
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    Our first discussion in great detail will be neutrophilic leukocytosis. Remember, please, the normal count of neutrophilic or WBC count should be between 4,500 to 11,000. So now, you have noticed that your patient has an increase in WBC count. But specifically here, it’s a neutrophilic count. You have an absolute neutrophilic count greater than 7,000, where the normal limit of your neutrophils should be between 2,200 and 5,600. If you remember that, that’s up to you. At least know normal WBC count between 4,500 to 11,000. Here, we have an absolute neutrophil count being above 7,000. Normal, 2,200, 5,600. When are you going to bring your neutrophils? Acute inflammation. We had an entire section in which we briefly breezed through acute inflammation, or we talked about how you are then going to bring about -- well, remember, circulating pool, marginating pool. We talked about rolling, adhesion, transmigration, chemotaxis, and phagocytosis. Neutrophilic leukocytosis seen in acute inflammation, especially bacteria, infection wise. Sterile, well, you know about myocardial infarction. If your patient is suffering from acute myocardial infarction, one of the first cells that you’re going to bring in during acute, acute type of myocardial infarction, once again, would be neutrophils. And remember, around the third day or so, the neutrophils will then undergo apoptosis being replaced with monocytes or macrophages. The most common drug to then cause neutrophilic leukocytosis would be corticosteroids in which it then causes demargination. What that means to you is that it inhibits the adhesion molecules so that you have decreased marginating pool, neutrophil increase in circulating pool. Keep in mind that whenever you do a CBC and you’re looking for a WBC count, in this case, your neutrophil count, then you’re always going to measure the circulating pool. Cytokine stimulation. Well, you could have something...

    About the Lecture

    The lecture Quantitative WBC Disorders: Neutrophilic Leukocytosis – White Blood Cell Pathology by Carlo Raj, MD is from the course Quantitative White Blood Cell Disorders – White Blood Cell Pathology (WBC).


    Included Quiz Questions

    1. 2,200 and 5,600 /mm/mm3
    2. 3,500 and 6,600 /mm/mm3
    3. 3,200 and 4,500 /mm/mm3
    4. 1,200 and 8,000 /mm/mm3
    5. 2,000 and 4,600 /mm/mm3
    1. Chemotaxis, rolling, adhesion, transmigration, phagocytosis
    2. Rolling, adhesion,chemotaxis, transmigration, phagocytosis
    3. Chemotaxis, adhesion, rolling, transmigration, phagocytosis
    4. Chemotaxis, transmigration, rolling, adhesion, phagocytosis
    5. Chemotaxis, rolling,transmigration, adhesion, phagocytosis
    1. IL-17
    2. IL-15
    3. IL-23
    4. IL-11
    5. IL-14
    1. Demargination
    2. Adhesion
    3. Rolling
    4. Chemotaxis
    5. Transmigration
    1. Leukemoid reaction
    2. Chronic lymphogenous leukemia
    3. Aplastic anemia
    4. Chronic myelogenous leukemia
    5. Pernicious anemia
    1. Infectious mononucleosis
    2. Splenic abnormalities
    3. Small cell lung cancer
    4. Thalassemia
    5. Breast cancer

    Author of lecture Quantitative WBC Disorders: Neutrophilic Leukocytosis – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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