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Postganglionic Sympathetic Nerve Terminal Blockers and Monoamine Oxidase Inhibitors – Drugs in Hypertension
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Slides Hypertension CardiovascularPharma.pdf
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Download Lecture Overview
00:01 Monoamine oxidase inhibitors actually do have some blood pressure activity. 00:07 Remember that MAOs cause a false transmitter. 00:11 They do cause lowering of blood pressure. 00:14 In fact, even in patients who are using monoamine oxidase inhibitors for depression will have a reduction in blood pressure. 00:23 In fact, if you take a look at your psychiatric medication lecture, and today's lecture, you'll see that I stole this image from the psychiatry lecture. 00:33 Now, one of the things I mentioned to you before in the psychiatry lecture is Foods high in tyramine like cheese and wine can cause a release of a large amount of noradrenaline, or norepinephrine. 00:46 And this can cause a large increase in blood pressure. 00:49 Have a look at that other lecture in antidepressants, and you can see how that works. 00:56 Now, these drugs have frequent side effects, they're not very effective and as I said before, they're not used a lot. 01:02 Once again, doctors hate these drugs for hypertension and never think about it. 01:07 but pharmacologist love these drugs and put them on exams in the hypertension section. 01:12 I'm not going to say that about its use in depression because in depression, we do use them more than we do in hypertension.
About the Lecture
The lecture Postganglionic Sympathetic Nerve Terminal Blockers and Monoamine Oxidase Inhibitors – Drugs in Hypertension by Pravin Shukle, MD is from the course Cardiovascular Pharmacology. It contains the following chapters:
- Postganglionic Sympathetic Nerve Terminal Blockers
- Monoamine Oxidase Inhibitors
Included Quiz Questions
What is the mechanism of action of desipramine?
- It inhibits the reuptake of norepinephrine.
- It inhibits the release of norepinephrine.
- It stimulates the reuptake of monoamine neurotransmitters including norepinephrine.
- It degrades norepinephrine.
- It degrades dopamine.
Which statement regarding monoamine oxidase inhibitors is most accurate?
- They prevent the breakdown of monoamine neurotransmitters.
- They prevent the reuptake of monoamine neurotransmitters.
- They increase the reuptake of monoamine neurotransmitters.
- They deplete the nerve terminal of monoamine neurotransmitters.
- They prevent the release of monoamine neurotransmitters.
Author of lecture Postganglionic Sympathetic Nerve Terminal Blockers and Monoamine Oxidase Inhibitors – Drugs in Hypertension
Pravin Shukle, MD
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