Microcytic Anemia: Summary

by Carlo Raj, MD

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    00:01 Beautiful table here for you to take a look at.

    00:02 It summarizes all of your microcytic anemias.

    00:07 Here they are, iron deficiency.

    00:10 What you’re seeing here in green is quite important for you to pay attention to.

    00:13 But you should be able to walk through each and every single one of these labs.

    00:19 And once you do, I’m not going to go through this again.

    00:20 But all of this go through the green ones.

    00:24 Iron deficiency, there is going to be increased in red blood cell distribution width.

    00:26 What does that mean? No uniformity, all different sizes.

    00:30 And with iron deficiency anemia, you will find increase in total iron binding capacity because the ferritin is decreased.

    00:36 Anemia of chronic disease, here you will find either normal or increased ferritin.

    00:45 The opposite of iron deficiency anemia.

    00:46 Why might it would be increased? Remember anemia of chronic disease, give me the 2 categories that you will this in? Good.

    00:53 It will either be in normocytic and may remain there.

    00:58 Or it might be microcytic as we see here.

    01:01 Thalassemia, iron studies are normal and your RBC count maybe perhaps increased but usually it will be variable so be careful there.

    01:10 And red blood cell distribution width will be increased here.

    01:13 Otherwise, take a look at your iron studies thalassemia.

    01:14 Yeah, perfectly normal, alpha or beta, right? Next, sideroblastic, what does this mean? Give me the most common acquired? Good. Alcohol.

    01:25 Give me the one in which maybe a child or a baby was crawling towards paint chips and eating it.

    01:31 Good. Lead poisoning.

    01:34 And what if there is a patient that have tuberculosis taking INH without B6? Good, there it is, INH poisoning, right? And what’s the rate-limiting enzyme in the porphyria pathway? ALA synthase and genetically, you might be missing that.

    01:50 You’ll begin with iron overload for the most part.

    01:51 Okay, remember ring sideroblasts.

    About the Lecture

    The lecture Microcytic Anemia: Summary by Carlo Raj, MD is from the course Microcytic Anemia – Red Blood Cell Pathology (RBC).

    Included Quiz Questions

    1. Low ferritin
    2. Low red blood cell count
    3. None of the options provided differentiate iron deficiency anemia from anemia of chronic disease.
    4. Low serum iron
    5. Mild microcytosis

    Author of lecture Microcytic Anemia: Summary

     Carlo Raj, MD

    Carlo Raj, MD

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    Great lecture
    By Sana Q. on 26. March 2018 for Microcytic Anemia: Summary

    Thank you Dr Raj, it was a very good lecture and your humor was keeping me interested in the topic.

    Hematology Anemia
    By Odette H. on 12. December 2017 for Microcytic Anemia: Summary

    It is was precise and clear lecture of anemias.. Thank you so much Dr. Raj!