Mesoderm Derivatives: Lateral Plate Mesoderm and Body Wall

by Peter Ward, PhD

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    00:01 Let´s return now to the last part of the mesoderm, the lateral plate mesoderm.

    00:06 So recall that we´ve got the notochord right in the center of the mesoderm setting up the different areas, the paraxial mesoderm which becomes somites, the intermediate mesoderm which becomes the gonads and kidneys and most laterally we have the lateral plate mesoderm.

    00:22 The first thing that happens is on day 19 or so in this lateral plate mesoderm is that we have the formation of little spaces, coelomic spaces, and with other spaces that we´ve seen before the same process will happen here.

    00:36 They´re going to be enlarged and fused and as they do so they form a space called intraembryonic coelom or the space within the embryo.

    00:45 Now, this space is gonna get larger and larger and as it does so, it splits the lateral plate mesoderm into an upper portion that´s in contact with the amniotic cavity and the ectoderm that´s called the somatic layer of the lateral plate mesoderm and the lower layer that´s in contact with the endoderm that´s going to be the visceral layer of lateral plate mesoderm.

    01:06 Now, as that intraembryonic coelom gets larger and larger, the somatic layer closely associates with the ectoderm and actually gets a new name, the somatopleure.

    01:16 So when you talk about somatopleure that´s referring to both the ectoderm and the somatic layer of lateral plate mesoderm together.

    01:24 Likewise, the portion of lateral plate mesoderm, the visceral layer, that´s in contact with the endoderm when we put those two together we collectively refer to it as the splanchnopleure.

    01:36 So splanchno is a prefix that means organs or visceral area and that´s going to be exactly what happens with this layer, it´s gonna form some of our organs.

    01:46 Now, as those fully separate, the somatic layer of lateral plate mesoderm grows outward and then folds ventrally and wraps around the splanchnopleure.

    01:58 So somatopleure enlarges and begins to wrap around the splanchnopleure starting roughly on the 22nd day of development, but by day 24 it´s moved even further around and the splanchnopleure has pinched off a small region of the definitive yolk sac.

    02:15 And just as the primitive yolk sac was separated into the definitive yolk sac and extra coelomic spaces, the gut tube is forming here and pushing the rest of the yolk sac further away.

    02:29 And by day 26, the definitive yolk sac is more or less been pushed outside of the developing body all together and what´s left of it inside the body is going to form the gut tube.

    02:40 And those lateral plate mesoderm somatic layer and ectoderm, once again the somatopleure, has completely wrapped around the embryo and seals itself shut on the midline and this creates the actual body cavity and this is what allows us to move from a plate of cells, a little three layered cellular structure, into an actual tube containing our organs and the intraembryonic coelom is now completely within the developing embryo and is gonna form our body cavities.

    03:13 Thank you very much, and we´ll return and discuss the formation of endoderm derived structures.

    03:20 The lateral mesoderm is responsible for the formation of limbs, myotome, the heart, lungs, and the different intra-abdominal organs.

    03:29 Therefore, a defective development of this structure might be associated with cardiac malformations, lung malformations and/or abdominal wall defects.

    About the Lecture

    The lecture Mesoderm Derivatives: Lateral Plate Mesoderm and Body Wall by Peter Ward, PhD is from the course Early Development and the Organogenic Period.

    Included Quiz Questions

    1. Somatopleure
    2. Somite
    3. Splanchnopleure
    4. Meningopleure
    5. Amnion
    1. Somatopleure
    2. Splanchnopleure
    3. Meningopleure
    4. Somite
    5. Amnion

    Author of lecture Mesoderm Derivatives: Lateral Plate Mesoderm and Body Wall

     Peter Ward, PhD

    Peter Ward, PhD

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    excellent lecture
    By Zijun Z. on 28. December 2018 for Mesoderm Derivatives: Lateral Plate Mesoderm and Body Wall

    w/ very clear explanations! i also like how the points are very clinically relevant. thank you!

    Thank you!!
    By Juan A. on 14. September 2018 for Mesoderm Derivatives: Lateral Plate Mesoderm and Body Wall

    The lectures are concise, very to the point but yet hit all the critical points and it is very easy to understand. Embryology for me is really difficult to picture. However, after watching these videos, I feel as though I can finally make sense out of what I am reading and what is being presented in class.