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Mechanism of Insulin Action & Types of Metabolism – Endocrine Pancreatic Hormones

by Carlo Raj, MD
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    Mechanism action of insulin, it will bond to glucose transporters or the receptor. When the receptor is bound to, there is something called autophosphorylation, which is important for you to know, intercellular beta subunit receptors and please note that it works from tyrosine kinase. When you have tyrosine kinase, this then represents your phosphorylation, phosphorylation. Now, every once in a while, they will ask about type 2 diabetes. Think about type 2 diabetes, where is my problem? Sure, it could be decreased insulin, but really the problem could be at the level of the receptor, take a look at the picture here. You see the phospholipid bilayer, you have a membrane, the spiraling blue ribbons that you see there, those are the receptors. It is then bound to two beta subunits, then you have the autophosphorylation. My point is this. The receptors might be resistant to insulin which are the round green circles. If the receptors to insulin are then insensitive or provide resistance, where is all my glucose? It is not being taken up by the cell, it remains back in my circulation, welcome to hyperglycemia, welcome to diabetes mellitus. What was that signaling pathway through your receptor? Tyrosine kinase. Oh no, you don’t find receptor resistance as being an answer choice. Post receptor defect is a huge area of interest in diabetes mellitus and when you say post receptor defect, you are referring to the fact that the signaling through tyrosine kinase might not be taking place appropriately, type 2 diabetes mellitus. Gene transcription can be up or down regulated depending as to what the level of glucose intake is. In muscles and fat, glucose entry into the cell through plasma membrane is enhanced by these glucose transporters; glucose 4 transporters are in fact insulin dependent. Which ones...

    About the Lecture

    The lecture Mechanism of Insulin Action & Types of Metabolism – Endocrine Pancreatic Hormones by Carlo Raj, MD is from the course Pancreatic Disease & Diabetes.


    Included Quiz Questions

    1. Tyrosine kinase activity
    2. Serine-threonine activity
    3. G-coupled protein activity
    4. JAK-STAT activity
    5. Ras-Raf activity
    1. GLUT-4
    2. GLUT-1
    3. GLUT-2
    4. GLUT-3
    5. GLUT-5
    1. Increases hormone sensitive lipase
    2. Increases glycerol synthesis
    3. Increases glycolysis
    4. Increased synthesis of triglycerides
    5. Increased fatty acid synthesis
    1. Increased amino acid uptake
    2. Decreased protein synthesis
    3. Increased protein breakdown
    4. Increased gluconeogenesis
    5. Increased glycerol synthesis

    Author of lecture Mechanism of Insulin Action & Types of Metabolism – Endocrine Pancreatic Hormones

     Carlo Raj, MD

    Carlo Raj, MD


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