MAOIs: In a Nutshell (Nursing)

00:00 So, let's wrap up this video series.

00:02 MAOIs inhibit MAO-A in the nerve terminal that gives an increased amount of norepinephrine and 5-HT.

00:10 Now, monoamine neurotransmitters, remember the three we discussed, serotonin, norepinephrine, and dopamine are used to relay signals between nerve cells and regulate important functions throughout the body.

00:23 MAOIs inhibit monoamine oxidase, and so, the body ends up with excess norepinephrine and can't rid itself of it.

00:33 So, remember if a patient eats a tyramine containing food, they're going to have a hypertensive crisis.

00:40 So, your role in educating the patient, making sure they truly understand which foods and drink contain tyramine, is critically important.

00:50 Now, serotonin syndrome is rare, but potentially life-threatening.

00:56 So, hyperserotonergic, that's creating an elevated serotonergic symptom is a medical condition.

01:03 MAOI inhibitors and serotonergic drugs like the ones you see listed there are likely to lead to serotonin syndrome.

01:13 Serotonin syndrome can also occur when combining MAOIs with certain opioids like meperidine and the other groups of medication that we discussed in the video.

01:22 So, MAOIs should not be combined with other antidepressants, most notably tricyclics, as they too, may result in a hypertensive crisis.

01:33 Thank you for watching our video today.