00:01
Hepatocellular carcinoma (HCC)
A specific tumor within the liver.
00:06
Anything that causes cirrhosis,
any cause of cirrhosis,
you're at risk for HCC.
00:13
So, alcohol, sure.
00:17
Non alcohol, yes.
00:18
Give me two major differentials of
non-alcoholic issues.
00:23
Autoimmune or maybe perhaps NASH.
00:26
Continue...
00:27
What about autoimmune?
What about Hemochromatosis?
What about a whole
holes of differentials
that may result in cirrhosis.
00:35
Hepatitis C.
00:39
Imaging sufficient with
background cirrhosis.
00:42
And that background cirrhosis
means what to you?
Where fibrosis kicking in,
tell me the size of the liver
versus the original size,
shrunken.
00:52
Biopsy, not always useful.
00:54
Imaging is sometimes sufficient.
00:57
Here, with the Hepatocellular carcinoma,
expect her to be increased in
alpha-fetoprotein.
01:02
Metastasis to the lung, bone and brain.
01:07
So this is a primary Hepatocellular carcinoma
that may have resulted, let's say,
from cirrhosis
and from the liver.
01:15
It might metastasis,
go up to the lung,
and then near
the bone and near the brain.
01:20
Important areas of Metastasis.
01:22
The treatment. Obviously, resection.
01:25
Transplantation is high
on that list.
01:28
You have chemo-embolization.
01:29
Maybe percutaneous,
ablation, and we have
sorafenib.
01:36
Metastasis.
01:38
Just like many the cancers
we have discussed,
at times the most common cancer
of that particular organ would be
Metastasis from a primary.
01:47
That is the topic for this section.
01:50
Most frequent site of metastasis
is from the GI tract,
limited role of the resection in case of
Colorectal Cancer (CRC).
01:58
In Colorectal cancer,
you need to make sure, you
always check to see is to whether not
it is then Metastasized.