Quantitative WBC Disorders: Lymphocytosis – White Blood Cell Pathology

by Carlo Raj, MD

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    Lymphocytosis. In the previous discussion, we looked at neutrophilic leukocytosis in great detail. Let’s go ahead and now take a look at what causes lymphocytosis. Elevated WBC count. Yes, that’s where you begin. And now, you have an absolute lymphocyte count greater than 4,000. In adults or in a child, even higher, 8,000. What's your WBC count? Good, 4,500 to 11,000. If you can remember, it’s some of these individual lymphocytes. What kind of infection causes more lymphocytosis? Viral or bacterial, especially viral, but it could also be bacterial. I gave you bordetella pertussis. Chronic inflammation. What does that mean to you? At some point in time, the neutrophils now disappear or undergo apoptosis. They’re being replaced by macrophages and lymphocytes and drugs. Notice as an example, I did not put corticosteroids. Corticosteroids would cause lymphopenia. You must memorize that if you haven’t already. The drug that I gave in your example would be anti-convulsive therapy and phenytoin. With lymphocytosis, increased production might be a possibility, or decreased entry into lymph node. Welcome to bordetella pertussis, which is a bacteria. In other cases, you’d find lymphocytosis. Antigenic stimulation of T-cells causes them to take an atypical morphologic change. If we’re talking about EBV, and remember infectious mononucleosis, we’re referring to Epstein-Barr virus. I’ll show you a picture coming up, and the picture will be a lymphocyte, which looks atypical. Oftentimes, it’s the nucleus. Think about the nucleus of lymphocyte. What does it look like? A sphere. Sometimes in pathology, recall an atypical lymphocyte that is found in EBV or CMV as a ballerina skirt. You’ll see what I’m referring to. Heterophile antibodies in acute phase is known as a monospot test, very, very sensitive. This is what you’ll be using the United States for your practice, especially in adolescence. If...

    About the Lecture

    The lecture Quantitative WBC Disorders: Lymphocytosis – White Blood Cell Pathology by Carlo Raj, MD is from the course Quantitative White Blood Cell Disorders – White Blood Cell Pathology (WBC).

    Included Quiz Questions

    1. Lymphopenia
    2. Anemia
    3. Thrombocytopenia
    4. Polycythemia
    5. Leukemia
    1. Phenytoin
    2. Dexamethasone
    3. Budesonide
    4. Methylprednisolone
    5. Prednisolone
    1. Infectious mononeucleosis
    2. Syphilis
    3. Tuberculosis
    4. Gonorrhea
    5. Rubella
    1. Downey Cells
    2. Burr cells
    3. Bite cells
    4. Popcorn cells
    5. Basket cells

    Author of lecture Quantitative WBC Disorders: Lymphocytosis – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD

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