Overview – Local Anesthetics

by Pravin Shukle, MD

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    About the Lecture

    The lecture Overview – Local Anesthetics by Pravin Shukle, MD is from the course CNS - Pharmacology.

    Included Quiz Questions

    1. The medications change from polar to non-polar, pass through the membrane, and then return to an active, polar form.
    2. Active transport pumps the medication into the nerve cells.
    3. Endocytosis at the synaptic cleft.
    4. The medication is converted into a base locally, with the use of a bicarbonate adjuvant. Once modified the medication is activated in the kidney and returned to locally anesthetize the tissue.
    5. The medication interacts with the extracellular matrix, resulting in a secondary messengers cascade to cause anesthesia.
    1. Distribution of nodes of Ranvier
    2. Size of the nerve fiber
    3. Myelination of the nerve fiber
    4. Activity of the nerve fiber
    5. Location of the fiber in the nerve bundle
    1. Hypercalcemia due to multiple myeloma
    2. Undiagnosed hyperkalemia
    3. Drug seeking behavior
    4. Anxiety
    5. Metabolic alkalosis
    1. Neural tissue
    2. Skeletal muscle
    3. Skin and adipose
    4. Tendons and ligaments
    5. Cardiac muscle

    Author of lecture Overview – Local Anesthetics

     Pravin Shukle, MD

    Pravin Shukle, MD

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    great lectures
    By Kristin S. on 22. January 2018 for Overview – Local Anesthetics

    I've never heard someone explain pKa and drug mechanism so simply before.