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Liver Diseases of Pregnancy

by Carlo Raj, MD
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    Liver Diseases of Pregnancy A big topic for us. Liver diseases in pregnancy. I'll give you two tables that are coming up. In which we will go through the explanations on the top, and the comments, and give you a quick little treatment measure. First one, Hyperemesis gravidarum. Nausea and vomiting is what you're looking for, dehydration in the first trimester. Pay attention to the trimester of your pregnant woman. Here you find your Bilirubin levels to be extremely high, upper limit of normal or your ALT to be incredibly high. Hyperemesis gravidarum, with all these vomiting, you can expect there to be decreased blood pressure. Thus, hydration becomes important and resolves spontaneously, which is always a good thing. Intra-hepatic cholestasis of pregnancy. What's that mean to you? That means that, the liver is having a hard time getting the bowel out of the pregnant woman's liver. How's your patient going to present? Pruritis and jaundice in second or third trimester. Here the bilirubin will be elevated by ten times greater than upper limit of normal. Treatment here, Cholestyramine, which is the resin, UDCA or ultimately deliveries, which you're thinking of. Keep Cholestyramine in play. Hepatic rupture, liver disease in pregnancy. This is where the patient in the third trimester, severe abdominal pain and the patient goes into shock Hepatic rupture. Treatment, no doubt, surgery. You want to keep Hyperemesis gravidarum, Intra-hepatic cholestasis pregnancy for sure in mind, Hepatic rupture is a state of emergency. To continue our discussion of liver diseases of pregnancy, we're coming into a phenomenon known as Pre-eclampsia. You want to group together Pre-eclampisa and HELLP. And the reason for that is because HELLP is worst case scenario of Pre-eclampsia. So what is Pre-eclampsia? From henceforth, Eclampsia is defined as seizures in a pregnant woman. This...

    About the Lecture

    The lecture Liver Diseases of Pregnancy by Carlo Raj, MD is from the course Cirrhosis – Liver Diseases.


    Included Quiz Questions

    1. Hyperemesis gravidarum
    2. Acute fatty liver disease of pregnancy
    3. Intrahepatic cholestasis of pregnancy
    4. HELLP syndrome
    5. Pre-eclampsia
    1. Hepatic rupture
    2. Intrahepatic cholestasis of pregnancy
    3. HELLP syndrome
    4. Pre-eclampsia
    5. Acute fatty liver of pregnancy
    1. Magnesium sulfate treatment dose
    2. Magnesium sulfate prophylactic dose
    3. Delivery
    4. Cholestyramine
    5. Spontaneously resolves
    1. Delivery of the fetus
    2. Use cholestyramine
    3. Prophylactic doses of magnesium sulfate
    4. Treatment doses of magnesium sulfate
    5. Monitor the blood pressure every 6 hours
    1. Pre-eclampsia
    2. Eclampsia
    3. HELLP syndrome
    4. Intrahepatic cholestasis
    5. Acute fatty liver of pregnancy
    1. Seizures
    2. Increased unconjugated bilirubin
    3. ALT levels >1000
    4. Platelets <100000 cells/dl
    5. High blood pressure
    1. Hepatic rupture
    2. Intrahepatic cholestasis of pregnancy
    3. Pre-eclampsia
    4. HELLP syndrome
    5. Acute fatty liver of pregnancy

    Author of lecture Liver Diseases of Pregnancy

     Carlo Raj, MD

    Carlo Raj, MD


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