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Leiomyoma vs. Leiomyosarcoma

by Carlo Raj, MD
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    About the Lecture

    The lecture Leiomyoma vs. Leiomyosarcoma by Carlo Raj, MD is from the course Uterine and Fallopian Tube Disease.


    Included Quiz Questions

    1. It has a high potential of malignant transformation.
    2. It is a benign tumor.
    3. It is estrogen responsive.
    4. It is a tumor of smooth muscle of the uterus.
    5. The size and location of the tumor within myometrium are variable.
    1. Compression of the urinary bladder leading to increased frequency of urination.
    2. Compression of the rectum leading to constipation and hemorrhoids.
    3. Severe, recurrent pelvic pain
    4. Compression of Fallopian tube opening leading to ectopic pregnancy.
    5. Compression of uterine arteries leading to myometrial ischemia.
    1. Leiomyoma increases in size when there is high level of estrogen, e.g. pregnancy, and decreases in size after menopause.
    2. Leiomyoma transforms in leimyosarcoma when amount of estrogen in the blood stream increases.
    3. Leiomyoma can only form when there is very high level of estrogen in the blood stream e.g. with an estrogen secreting ovarian tumor.
    4. High levels of estrogen can cause involution of leiomyoma.
    5. Low levels of estrogen cause increase in size of leiomyoma, where as high levels produce the opposite effect.
    1. Leiomyoma is well-circumscribed grossly, and well-differentiated microscopically. Leiomyosarcoma is the opposite in both respects.
    2. Leiomyoma is small in size grossly, and has fewer smooth muscles cells; leimoyosarcoma is huge and consequently, has very high number of tightly packed smooth muscle cells.
    3. Leiomyoma occurs only right below the endometrium, leiomyosarcoma occurs under the peritoneal lining. Microscopically, they are the same.
    4. Leiomyoma is white in color grossly, and is microscopically composed of white smooth muscle cells with abundant collagen stroma. Leimyosarcoma is red grossly, and has a very high number of blood vessels microscopically.
    5. Leiomyoma and leiomyosarcoma can not be differentiated on microscopy. Special staining techniques and electron microscopy are required for diagnosis.

    Author of lecture Leiomyoma vs. Leiomyosarcoma

     Carlo Raj, MD

    Carlo Raj, MD


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