Leiomyoma vs. Leiomyosarcoma

by Carlo Raj, MD

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    About the Lecture

    The lecture Leiomyoma vs. Leiomyosarcoma by Carlo Raj, MD is from the course Uterine and Fallopian Tube Disease.

    Included Quiz Questions

    1. It has a high potential for malignant transformation.
    2. It is a benign tumor
    3. It is estrogen responsive
    4. It is a tumor of smooth muscle of the uterus.
    5. The size and location of the tumor within myometrium are variable.
    1. Compression of the urinary bladder leading to increased frequency of urination
    2. Compression of the rectum leading to constipation and hemorrhoids
    3. Severe, recurrent pelvic pain
    4. Compression of the fallopian tube opening leading to ectopic pregnancy
    5. Compression of uterine arteries leading to myometrial ischemia
    1. Leiomyoma increases in size when there is a high level of estrogen, e.g. pregnancy, and decreases in size after menopause.
    2. Leiomyoma transforms into leimyosarcoma when the amount of estrogen in the blood stream increases.
    3. Leiomyoma can only form when there is very high level of estrogen in the blood stream e.g. with an estrogen secreting ovarian tumor.
    4. High levels of estrogen can cause involution of leiomyoma.
    5. Low levels of estrogen cause increase in size of leiomyoma, where as high levels produce the opposite effect.
    1. Leiomyomas are well-circumscribed grossly, and well-differentiated microscopically whereas leiomyosarcomas are the opposite in both respects.
    2. Leiomyomas are small in size grossly, and have fewer smooth muscle cells; a leimoyosarcoma is huge and consequently, has a very high number of tightly packed smooth muscle cells.
    3. Leiomyomas occur only right below the endometrium whereas leiomyosarcomas occur under the peritoneal lining, but microscopically, they are the same.
    4. Leiomyomas are white in color grossly, and is microscopically composed of white smooth muscle cells with abundant collagen stroma. Leimyosarcomas are red grossly, and have a very high number of blood vessels microscopically.
    5. Leiomyomas and leiomyosarcomas cannot be differentiated on microscopy. Special staining techniques and electron microscopy are required for diagnosis.

    Author of lecture Leiomyoma vs. Leiomyosarcoma

     Carlo Raj, MD

    Carlo Raj, MD

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