00:02 Let’s take a look at an interleukin-1 blocker. 00:05 Now, Kineret is a well-known drug, it is an interleukin-1 antagonist and it is often used in the treatment of rheumatoid arthritis but we also can use it in newer onset multisystem autoimmune diseases in the inflammatory diseases. 00:21 We have some certain syndromes that are being treated with this so the treatments are just starting out in rheumatoid arthritis and slowly expanding into other autoimmune diseases. 00:33 Now avoid this medication in patients who have active infections. 00:38 It makes sense that suppressing the immune system in a person who's sick and infected is not gonna end well. 00:45 Avoid this drug in latent tuberculosis so even though they don’t have an active infection you can risk people getting very sick in the case of a reactivation. 00:56 Avoid this drug in patients who have low white blood cell counts and avoid this drug on people who have been taking tumor necrosis factor inhibitors. 01:06 The adverse events associated with this medication usually, all of them I would say, injection site reactions but also look out for some neurological symptoms like headaches. 01:16 Sometimes you can have rise in cholesterol through an unknown mechanism and finally severe infection. 01:22 So we have seen patients for example who decided to take this medication for the treatment of their rheumatoid arthritis end up in the hospital with quite severe life-threatening infections so be very aware that sometimes these drugs can have serious consequences if they're not given to the right patient. 01:41 Next we have the interleukin-6 inhibitors. 01:44 Now these blockers of interleukin-6 are often used in rheumatoid arthritis - systemic rheumatoid arthritis and juvenile rheumatoid arthritis. 01:54 We also have used it in patients who have multiple myeloma and, in some cases, now we're starting to use it in prostate cancer. 02:02 It seems counter intuitive to use an IL-6 inhibitor in prostate cancer but there are certain mechanisms that actually reduce the progression of prostate cancer using IL-6 inhibitors.
The lecture Interleukin-1 and Interleukin-6 Inhibitor – Immunosuppressive Drugs by Pravin Shukle, MD is from the course Inflammation Pharmacology.
Anakinra is an IL-1 inhibitor that is indicated for which condition?
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