Interleukin-1 and Interleukin-6 Inhibitor – Immunosuppressive Drugs

by Pravin Shukle, MD

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    00:02 Let’s take a look at an interleukin-1 blocker.

    00:05 Now, Kineret is a well-known drug, it is an interleukin-1 antagonist and it is often used in the treatment of rheumatoid arthritis but we also can use it in newer onset multisystem autoimmune diseases in the inflammatory diseases.

    00:21 We have some certain syndromes that are being treated with this so the treatments are just starting out in rheumatoid arthritis and slowly expanding into other autoimmune diseases.

    00:33 Now avoid this medication in patients who have active infections.

    00:38 It makes sense that suppressing the immune system in a person who's sick and infected is not gonna end well.

    00:45 Avoid this drug in latent tuberculosis so even though they don’t have an active infection you can risk people getting very sick in the case of a reactivation.

    00:56 Avoid this drug in patients who have low white blood cell counts and avoid this drug on people who have been taking tumor necrosis factor inhibitors.

    01:06 The adverse events associated with this medication usually, all of them I would say, injection site reactions but also look out for some neurological symptoms like headaches.

    01:16 Sometimes you can have rise in cholesterol through an unknown mechanism and finally severe infection.

    01:22 So we have seen patients for example who decided to take this medication for the treatment of their rheumatoid arthritis end up in the hospital with quite severe life-threatening infections so be very aware that sometimes these drugs can have serious consequences if they're not given to the right patient.

    01:41 Next we have the interleukin-6 inhibitors.

    01:44 Now these blockers of interleukin-6 are often used in rheumatoid arthritis - systemic rheumatoid arthritis and juvenile rheumatoid arthritis.

    01:54 We also have used it in patients who have multiple myeloma and, in some cases, now we're starting to use it in prostate cancer.

    02:02 It seems counter intuitive to use an IL-6 inhibitor in prostate cancer but there are certain mechanisms that actually reduce the progression of prostate cancer using IL-6 inhibitors.

    About the Lecture

    The lecture Interleukin-1 and Interleukin-6 Inhibitor – Immunosuppressive Drugs by Pravin Shukle, MD is from the course Inflammation Pharmacology.

    Included Quiz Questions

    1. Rheumatoid arthritis
    2. Active infections
    3. Latent TB
    4. Leukopenia
    5. Patients on TNF inhibitors

    Author of lecture Interleukin-1 and Interleukin-6 Inhibitor – Immunosuppressive Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD

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