Hormonal Control/Signaling

by Kevin Ahern, PhD

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    00:01 So in summary what we have seen over the past couple of pathways are as follows.

    00:04 Epinephrine, glucagon binding stimulates the phosphorylation of all glycogen enzymes.

    00:11 The phosphorylation of the glycogen breakdown enzymes like glycogen phosphorylase will activated favoring glycogen breakdown.

    00:19 Phosphorylation of the glycogen synthesis enzyme, glycogen synthase, inactivates it.

    00:23 Epinephrine also activates glycogen breakdown and glucose production.

    00:29 Now if you think about that, that makes sense if the AM is putting glucose out.

    00:34 Glucose production comes from gluconeogenesis and glycogen breakdown produces glucose so that it can be exported from cells.

    00:42 These two events are coordinated so that the body has the glucose that it needs.

    00:48 Epinephrine inactivates glycogen synthesis and that makes sense; because the glucose that you are producing, you don't wanna waste in a futile cycle.

    00:56 On the opposite site, insulin stimulates phosphoprotein phosphatase. So when insulin is present, blood glucose is high and the body is wanting to deal with it.

    01:07 This stimulates the removal of phosphates from all the proteins that we have talked about before.

    01:12 That's going to reverse all of those effects. Glycogen breakdown enzymes become less active meaning that they are not breaking down glycogen anymore.

    01:20 And the glycogen synthase becomes active so it's gonna grab that glucose that's coming in and deal with it.

    01:27 So cells start making glycogen instead of breaking it down.

    01:31 And cells will also start breaking it down in glycolysis instead of making it in gluconeogenesis.

    01:38 So epinephrine and glucagon are stimulated in the production of glucose.

    01:42 Whereas insulin is stimulating the use of that glucose in the synthesis of glycogen.

    About the Lecture

    The lecture Hormonal Control/Signaling by Kevin Ahern, PhD is from the course Metabolic Control.

    Included Quiz Questions

    1. Insulin
    2. Glucagon
    3. F2,6BP
    4. Adrenaline

    Author of lecture Hormonal Control/Signaling

     Kevin Ahern, PhD

    Kevin Ahern, PhD

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