Hereditary, Toxic and Infectious Neuropathy

by Carlo Raj, MD

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    We’ll take a look at types of hereditary neuropathy. Under here, we’ll take a look at a very important differential, and this is called Charcot-Marie-Tooth disease. We’ll take a look at amyloid neuropathies. We have what’s known as HNPP, hereditary neuropathy with liability to pressure palsies. Pressure palsies. And we have hereditary sensory and autonomic neuropathy, and that actually will make perfect sense because the name will imply exactly what’s going on with your patient. And then you have neuropathy with what’s known as leukodystrophy. These are hereditary neuropathies. Most prevalent inherited neurologic disease we’ll take a look at would be Charcot-Marie, CMT, Charcot-Marie-Tooth. There are multiple types. There are. We have CMT Type 1, 2, and such. High variability in symptoms even within the family, even though it’s hereditary. All are demyelinating except the CMT-2, it’s an axonal CMT. No specific treatment available, however. Under toxic neuropathy. Heavy metals: arsenic, your patient might be exposed to water, lead, mercury, thallium. Drugs such as vincristine, cisplatin, anti-retrovirals. Substance abuse such alcohol, glue inhalation, and of course, nitric oxide type of inhalation, or nitrous oxide. Industrial poisons: These are risk factors for toxic neuropathy. Infectious neuropathy: HIV, Lyme, leprosy, most common neuropathy in the world, actually, and even -- well, think about your immunocompromised patients here, and CMV and herpes. There are many type of neuropathies in which we are going to walk through in terms of classifications. We'll begin by looking at infectious neuropathy. We have HIV. Distal sensory polyneuropathy, one-third of your AIDS patients actually have distal sensory polyneuropathy. You have something called mononeuropathies, and this is typically later in the disease. So, if I were you, I would know the timeline here for HIV neuropathy, please. And may actually have and develop what’s known as acute inflammatory demyelinating...

    About the Lecture

    The lecture Hereditary, Toxic and Infectious Neuropathy by Carlo Raj, MD is from the course Polyneuropathy. It contains the following chapters:

    • Types of Hereditary Neuropathy
    • Toxic Neuropathy
    • Infectious Neuropathy

    Included Quiz Questions

    1. Lead
    2. Mercury
    3. Thallium
    4. Arsenic
    5. Alcohol
    1. Leprosy
    2. HIV
    3. Lyme disease
    4. CMV
    5. Herpes
    1. CMV virus
    2. Herpes virus
    3. Rabies virus
    4. West Nile virus
    5. Kaposi Herpes virus

    Author of lecture Hereditary, Toxic and Infectious Neuropathy

     Carlo Raj, MD

    Carlo Raj, MD

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