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Hepatorenal Syndrome

by Carlo Raj, MD
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    00:01 An important understanding of Hepatorenal Syndrome is required.

    00:07 This is a functional renal failure without underlying renal pathology.

    00:12 This is not nephralic syndrome, this is not nephrotic syndrome nor it is arteriosclerosis taking place at the renal artery.

    00:19 The perfectly functional kidney, used to be the patient developed portal hypertension and now, there is a functional renal failure Is that clear? Very interesting. Important? Yes.

    00:35 Type I: Severe with rapid renal failure.

    00:40 your GFR drops, mortality almost 100% So, from now on, whenever you have portal hypertension, you can now go beyond, just cure hepatic portal hypertension, can't you? An important topic.

    00:55 Type II: Insidious drop in GFR.

    00:58 Diagnosis of exclusion.

    00:59 Here, you'll find that urine sodium is less than 10mEq/L urine sodium is less than 10mEq/L It means to say, it is not able to properly take care of sodium handling.

    01:08 There is no established therapy which makes it really dangerous.

    01:12 And after transplantation of liver, it seems as though the kidney actually comes back to life.

    01:18 Fascinating. We don't know a whole lot about it but we know just enough, where that statistic of 100% mortality puts it on the radar, big time.


    About the Lecture

    The lecture Hepatorenal Syndrome by Carlo Raj, MD is from the course Cirrhosis – Liver Diseases.


    Included Quiz Questions

    1. Renal transplantation
    2. Chemotherapy
    3. Steroids
    4. Antibiotics
    5. Antihypertensives
    1. Rapidity in the loss of the renal function
    2. Amount of loss of renal function
    3. Severity of loss of renal function
    4. Severity of loss of hepatic function
    5. Rapidity of loss of hepatic function
    1. Type 2 shows rapid loss of renal function
    2. There is type 1 and type 2 hepatorenal syndrome
    3. It is defined as the functional renal failure without underlying renal pathology secondary to portal hypertension
    4. Type 1 hepatorenal syndrome has a high rate of mortality.
    5. Hepatorenal syndrome is usually a diagnosis of exclusion with urine Na<20 mEq/L
    1. Hepatorenal syndrome type 1 is reversible.
    2. Type 2 shows rapid loss of renal function
    3. Hepatorenal syndrome is treated with steroids and antihypertensives
    4. Hepatorenal syndrome is usually diagnosed with certainty based on the renal function only
    5. Hepatorenal syndrome does not improve after renal transplantation
    1. Serum creatinine - Increased Urine Na - Decreased Serum transaminases - Increased
    2. Serum creatinine - normal Urine Na - Decreased Serum transaminases - Increased
    3. Serum creatinine - Increased Urine Na - Decreased Serum transaminases - normal
    4. Serum creatinine - Increased Urine Na - increased Serum transaminases - Increased
    5. Serum creatinine - decreased Urine Na - Decreased Serum transaminases - decreased
    1. Type i Hepatorenal syndrome
    2. Type 2 hepatorenal syndrome
    3. Hepatopulmonary syndrome
    4. Non alcoholic liver disease
    5. Cirrhosis with portal hypertension

    Author of lecture Hepatorenal Syndrome

     Carlo Raj, MD

    Carlo Raj, MD


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