Hardy-Weinberg Principle

by Georgina Cornwall, PhD

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    Now, let’s get to the meat of this issue, the Hardy-Weinberg equation. You’ve seen it before, I’m certain. This is how we’re going to derive our genotypic frequencies from the allelic frequencies that we see in the population. It’s a little bit more tricky to go around this way because we have to use this fancy equation which I could show you the derivatives of but it’s not really important. What you need to know is that in this case, p squared equals the frequency of the dominant allele or one of the alleles. It's really pretty arbitrary whether you assign it to p or q. Q is the frequency of the other. So, 2pq is the frequency of the heterozygote and q squared is the frequency of the other gene form or by default, we’ll just call it the recessive form. So p squared, 2pq, and q squared covers all three of the genotypes that we were observing in the table. Now, you have a complete understanding, right? Anyway, we can then break it down and say that if we are looking at the allelic frequency, we can say the p is equal to the frequency of A and q is equal to the frequency of little a, such that the whole population is covered by this little guy at the bottom, the ratio of p squared, the ratio of 2pq, and the ratio of q squared. That covers our population. That’s how we might note these things. Again you might ask, why on Earth do I need to know this Hardy-Weinberg principle equation when I’m going to be a doctor, not a population geneticist? Well, the bottom line is you need to know it because it’s going to be on your exam. You see the exclamation point at...

    About the Lecture

    The lecture Hardy-Weinberg Principle by Georgina Cornwall, PhD is from the course Population Genetics. It contains the following chapters:

    • The Hardy-Weinberg Principle
    • The Hardy-Weinberg Law

    Author of lecture Hardy-Weinberg Principle

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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