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Hardy-Weinberg in X-Linked Disease

by Georgina Cornwall, PhD
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    While we’re here, why don’t we take a quick look at how Hardy-Weinberg works out with X-linked diseases? We’re all familiar with color blindness as being X-linked. So, I’ll ask the question, what is the frequency of female carriers? Now, I’ll give you a little hint that 8% of the population has red-green color blindness. Take a moment. See what you can do with that. Pause the video. Take out some paper. See what you can do to calculate the frequency of female carriers based on the fact that 8% of the population is color blind. Let’s see how you did. There’s a little bit of a trick when we consider X-linked traits. We can do it the normal way but a quick shortcut is looking at allelic frequency because we can look at it directly by looking at the male because the male is hemizygous. He only has one copy of X. By looking at how many males in the population or looking at the frequency of color blind males in the population, we can establish q very quickly. I know, kind of sneaky, huh? But either a way, I bet you came out with the right numbers. If we look at q and we say it’s 0.08 or 8% then we can easily, with some simple math, figure out that p is the remainder of that, 0.92. So, 92% of the alleles in the whole population are normal alleles. Now to the question what are we actually looking for? We’re looking for female carriers. Female carriers are going to be heterozygous. So, they are 2pq. All we need to do then is calculate 2pq, 2 x 0.08 x 0.92, you get the picture. We find out that actually color blindness is carried by 15% of women. That sounds...

    About the Lecture

    The lecture Hardy-Weinberg in X-Linked Disease by Georgina Cornwall, PhD is from the course Population Genetics.


    Author of lecture Hardy-Weinberg in X-Linked Disease

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD


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